best performing stock in the last 5 yrs with a market cap of 5 billion+

Regencell Bioscience (RGC) has had the highest return between August 12, 2020 and August 12, 2025 by a US stock with a market cap of $5B+, returning 4,181.2%.

ASSET DATE % RETURN
Regencell Bioscience (RGC)
8/12/2020 - 8/12/2025
4,181.19%
MicroStrategy (MSTR)
8/12/2020 - 8/12/2025
2,864.38%
Celestica (CLS)
8/12/2020 - 8/12/2025
2,338.62%
GameStop (GME)
8/12/2020 - 8/12/2025
1,937.27%
Dillards (DDS)
8/12/2020 - 8/12/2025
1,936.06%
Sterling Construction (STRL)
8/12/2020 - 8/12/2025
1,793.27%
Modine Manufacturing (MOD)
8/12/2020 - 8/12/2025
1,782.87%
Palantir Technologies Inc Class A Common Stock (PLTR)
8/12/2020 - 8/12/2025
1,726.8%
NVIDIA (NVDA)
8/12/2020 - 8/12/2025
1,561.94%
Super Micro Computer (SMCI)
8/12/2020 - 8/12/2025
1,523.56%
Permian Resources (PR)
8/12/2020 - 8/12/2025
1,501.33%
Verona Pharma PLC ADR (VRNA)
8/12/2020 - 8/12/2025
1,215.5%
Comfort Systems USA (FIX)
8/12/2020 - 8/12/2025
1,193.53%
Vistra Energy (VST)
8/12/2020 - 8/12/2025
1,080.22%
IES (IESC)
8/12/2020 - 8/12/2025
1,068.81%
Fortress Transp & Infra Inv (FTAI)
8/12/2020 - 8/12/2025
1,061.99%
Carpenter Technology (CRS)
8/12/2020 - 8/12/2025
991.6%
Broadcom (AVGO)
8/12/2020 - 8/12/2025
951.19%
Axon Enterprise (AXON)
8/12/2020 - 8/12/2025
928.51%
Arista Networks (ANET)
8/12/2020 - 8/12/2025
898.91%
Credo Technology (CRDO)
8/12/2020 - 8/12/2025
879.92%
Howmet Aerospace  (HWM)
8/12/2020 - 8/12/2025
879.75%
Embraer SA ADR (ERJ)
8/12/2020 - 8/12/2025
875.17%
Mr Cooper (COOP)
8/12/2020 - 8/12/2025
845.8%
Flex (FLEX)
8/12/2020 - 8/12/2025
845.1%