DarioHealth (DRIO) had the highest return between 2016 and 2020 by a US stock, returning 28,579,900%.

ASSET	YEARS	% RETURN
DarioHealth (DRIO)	2016-2020	28,579,900%
GreenPower Motor (GP)	2016-2020	9,096,775%
Amerant Bancorp (AMTB)	2016-2020	4,767,033.33%
KULR Technology (KULR)	2016-2020	2,939,900%
Integra Resources (ITRG)	2016-2020	783,900%
Immatics (IMTX)	2016-2020	215,700%
AquaBounty Technologies (AQB)	2016-2020	121,566.67%
Weatherford International (WFRD)	2016-2020	103,175.44%
ImmunoPrecise Antibodies (HYFT)	2016-2020	99,566.67%
Kaival Brands Innovations (KAVL)	2016-2020	71,566.6%
GeoVax Labs (GOVX)	2016-2020	66,610.53%
Alarum Technologies (ALAR)	2016-2020	41,787.91%
Metalla Royalty & Streaming (MTA)	2016-2020	36,121.45%
Freedom (FRHC)	2016-2020	34,106.67%
Blackboxstocks (BLBX)	2016-2020	26,100.87%
Avalon GloboCare (ALBT)	2016-2020	23,900%
Aura Minerals Inc Common Shares (AUGO)	2016-2020	15,196.27%
Gryphon Digital Mining (GRYP)	2016-2020	13,343.98%
HIVE Blockchain Technologies (HIVE)	2016-2020	11,712.5%
Gravity (GRVY)	2016-2020	11,126.09%
ABOT (ABOT)	2016-2020	9,526.31%
FingerMotion (FNGR)	2016-2020	7,952%
eXp World (EXPI)	2016-2020	7,414.04%
Quantum Computing (QUBT)	2016-2020	6,955%
GT Biopharma (GTBP)	2016-2020	6,871.66%