Amerant Bancorp (AMTB) had the highest return between 2018 and 2021 by a US stock, returning 10,854,266.7%.

ASSET	YEARS	% RETURN
Amerant Bancorp (AMTB)	2018-2021	10,854,266.67%
BioNexus Gene Lab Corp Common stock (BGLC)	2018-2021	6,234,046.34%
KULR Technology (KULR)	2018-2021	5,519,900%
GreenPower Motor (GP)	2018-2021	2,369,900%
Weatherford International (WFRD)	2018-2021	1,045,919.23%
Avalon GloboCare (ALBT)	2018-2021	768,650%
MicroCloud Hologram (HOLO)	2018-2021	577,362.44%
Integra Resources (ITRG)	2018-2021	358,233.33%
Immatics (IMTX)	2018-2021	268,700%
MDxHealth SA ADR (MDXH)	2018-2021	244,002.56%
Bone Biologics (BBLG)	2018-2021	222,831.78%
GeoVax Labs (GOVX)	2018-2021	110,490.63%
Applied Digital (APLD)	2018-2021	69,733.33%
Alarum Technologies (ALAR)	2018-2021	57,623.58%
Diversified Energy (DEC)	2018-2021	43,200%
FitLife Brands, Inc Common Stock (FTLF)	2018-2021	25,459.11%
Kaival Brands Innovations (KAVL)	2018-2021	12,321.67%
Nocera (NCRA)	2018-2021	11,960%
Enphase Energy (ENPH)	2018-2021	7,554.39%
Tandem Diabetes Care (TNDM)	2018-2021	6,305.11%
Xpel (XPEL)	2018-2021	4,674.83%
Fubotv (FUBO)	2018-2021	4,334.29%
Golden Matrix (GMGI)	2018-2021	4,180%
Nuvve (NVVEW)	2018-2021	3,583.33%
Digital Turbine (APPS)	2018-2021	3,288.33%