InterContinental Hotels Group PLC ADR (IHG) had the highest return between 1997 and 2011 by a US stock, returning 13,118,400%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	1997-2011	13,118,400%
AngloGold Ashanti (AU)	1997-2011	9,006,825%
QVC (QVCGA)	1997-2011	8,410,955.56%
Northern Oil & Gas (NOG)	1997-2011	7,735,369.23%
Castellum (CTM)	1997-2011	6,521,639.13%
Sequans Communications (SQNS)	1997-2011	3,349,297.59%
Houston American Energy (HUSA)	1997-2011	3,167,779.42%
Hirequest (HQI)	1997-2011	1,540,850%
National Grid PLC ADR (NGG)	1997-2011	1,307,958.82%
Know Labs (KNW)	1997-2011	992,216.79%
India Globalization Capital (IGC)	1997-2011	483,233.33%
Ferguson (FERG)	1997-2011	422,842.55%
Natwest (NWG)	1997-2011	400,280%
Perspective Therapeutics (CATX)	1997-2011	219,900%
Ring Energy (REI)	1997-2011	133,233.33%
Aris Mining (ARMN)	1997-2011	76,482.09%
First Majestic Silver (AG)	1997-2011	73,759.56%
Monster Beverage (MNST)	1997-2011	56,358.09%
Flexible Solutions International (FSI)	1997-2011	36,807.84%
Ocean Power Technologies (OPTT)	1997-2011	29,455.56%
Pioneer Power Solutions (PPSI)	1997-2011	15,915.77%
Inuvo (INUV)	1997-2011	15,677.78%
Cognizant Technology Solutions Corp Class A (CTSH)	1997-2011	15,334.99%
Gyre Therapeutics (GYRE)	1997-2011	11,710.35%
Companhia Siderurgica Nacional ADR (SID)	1997-2011	11,235.18%