Monster Beverage (MNST) had the highest return between 2001 and 2005 by a US stock in the S&P 500 (GSPC), returning 4,035.8%.

ASSET	YEARS	% RETURN
Monster Beverage (MNST)	2001-2005	4,035.77%
Tractor Supply (TSCO)	2001-2005	2,391.67%
Hologic (HOLX)	2001-2005	1,344.57%
Axon Enterprise (AXON)	2001-2005	1,093.23%
Apple (AAPL)	2001-2005	866.5%
CME (CME)	2001-2005	866.47%
Tapestry (TPR)	2001-2005	831.77%
Old Dominion Freight Line (ODFL)	2001-2005	809.8%
Cognizant Technology Solutions Corp Class A (CTSH)	2001-2005	727.04%
Western Digital (WDC)	2001-2005	626.25%
Intuitive Surgical (ISRG)	2001-2005	621.6%
CarMax (KMX)	2001-2005	602.97%
Freeport-McMoran Copper & Gold (FCX)	2001-2005	592.77%
Autodesk (ADSK)	2001-2005	558.82%
Global Payments (GPN)	2001-2005	534%
Texas Pacific Land Trust (TPL)	2001-2005	533.89%
F5 Networks (FFIV)	2001-2005	505.98%
NVR (NVR)	2001-2005	467.96%
Valero Energy (VLO)	2001-2005	460.47%
Centene (CNC)	2001-2005	452.68%
Deckers Outdoor (DECK)	2001-2005	452.34%
JB Hunt Transport Services (JBHT)	2001-2005	444.27%
Altria (MO)	2001-2005	434.15%
eBay (EBAY)	2001-2005	413.18%
Gilead Sciences (GILD)	2001-2005	403.67%