Netflix (NFLX) had the highest return between 2012 and 2018 by a US stock in the S&P 500 (GSPC), returning 2,565.9%.

ASSET	YEARS	% RETURN
Netflix (NFLX)	2012-2018	2,565.94%
Caesars Entertainment (CZR)	2012-2018	1,826.06%
Texas Pacific Land Trust (TPL)	2012-2018	1,300.8%
DexCom (DXCM)	2012-2018	1,158.4%
Tesla (TSLA)	2012-2018	1,049.99%
NVIDIA (NVDA)	2012-2018	909.64%
Broadcom (AVGO)	2012-2018	885.46%
Align Technology (ALGN)	2012-2018	763.99%
Amazon (AMZN)	2012-2018	753.93%
EPAM Systems (EPAM)	2012-2018	743.71%
Axon Enterprise (AXON)	2012-2018	734.92%
Monolithic Power Systems (MPWR)	2012-2018	731.35%
Domino's Pizza Inc Common Stock (DPZ)	2012-2018	728.26%
Constellation Brands Inc Class A (STZ)	2012-2018	699.14%
Adobe Systems (ADBE)	2012-2018	688.29%
MarketAxess (MKTX)	2012-2018	659.88%
ServiceNow (NOW)	2012-2018	649.68%
Take-Two Interactive Software (TTWO)	2012-2018	644.32%
HCA (HCA)	2012-2018	621.1%
Lennox International (LII)	2012-2018	585.67%
Paycom Soft (PAYC)	2012-2018	584.08%
Regeneron Pharmaceuticals (REGN)	2012-2018	560.94%
Delta Air Lines (DAL)	2012-2018	559.96%
Boston Scientific (BSX)	2012-2018	552.03%
Huntington Ingalls Industries (HII)	2012-2018	542%