Monster Beverage (MNST) had the highest return between 2004 and 2015 by a US stock in the S&P 500 (GSPC), returning 28,208.6%.

ASSET	YEARS	% RETURN
Monster Beverage (MNST)	2004-2015	28,208.55%
Apple (AAPL)	2004-2015	7,244.9%
Booking (BKNG)	2004-2015	6,963.44%
Regeneron Pharmaceuticals (REGN)	2004-2015	3,565.56%
Intuitive Surgical (ISRG)	2004-2015	3,093.92%
Netflix (NFLX)	2004-2015	2,684.93%
Mastercard (MA)	2004-2015	2,403.42%
Salesforce (CRM)	2004-2015	1,990.68%
Tyler Technologies (TYL)	2004-2015	1,691.57%
Transdigm (TDG)	2004-2015	1,541.12%
Incyte (INCY)	2004-2015	1,501.92%
Domino's Pizza Inc Common Stock (DPZ)	2004-2015	1,493.37%
Altria (MO)	2004-2015	1,476.23%
Alphabet Inc Class A (GOOGL)	2004-2015	1,454.39%
Texas Pacific Land Trust (TPL)	2004-2015	1,311.83%
Gilead Sciences (GILD)	2004-2015	1,302.95%
CF Industries (CF)	2004-2015	1,272.66%
LKQ (LKQ)	2004-2015	1,238.43%
O’Reilly Automotive (ORLY)	2004-2015	1,211.4%
Amazon (AMZN)	2004-2015	1,181.07%
Tesla (TSLA)	2004-2015	1,163.18%
Vertex Pharmaceuticals (VRTX)	2004-2015	1,115.75%
Chipotle Mexican Grill (CMG)	2004-2015	966.33%
Edwards Lifesciences (EW)	2004-2015	949.92%
Cognizant Technology Solutions Corp Class A (CTSH)	2004-2015	939.76%