Regeneron Pharmaceuticals (REGN) had the highest return between 2011 and 2012 by a US stock in the S&P 500 (GSPC), returning 423.3%.

ASSET	YEARS	% RETURN
Regeneron Pharmaceuticals (REGN)	2011-2012	423.31%
Domino's Pizza Inc Common Stock (DPZ)	2011-2012	192.28%
Ulta Beauty (ULTA)	2011-2012	191.12%
Generac (GNRC)	2011-2012	179.73%
Builders FirstSource (BLDR)	2011-2012	179%
Expedia (EXPE)	2011-2012	167.39%
Contura Energy (CTRA)	2011-2012	161.08%
PulteGroup (PHM)	2011-2012	138.32%
Tyler Technologies (TYL)	2011-2012	131.33%
Lululemon Athletica (LULU)	2011-2012	119.71%
Visa Inc Class A (V)	2011-2012	118.73%
Seagate Technology (STX)	2011-2012	118.29%
Mastercard (MA)	2011-2012	117.96%
Biogen (BIIB)	2011-2012	116.27%
LyondellBasell Industries (LYB)	2011-2012	112.44%
Targa Resources (TRGP)	2011-2012	108.66%
Lennar (LEN)	2011-2012	107.71%
Transdigm (TDG)	2011-2012	106.16%
Caesars Entertainment (CZR)	2011-2012	103.41%
Paramount Global Class B (PARA)	2011-2012	102.93%
Monster Beverage (MNST)	2011-2012	100.72%
Gilead Sciences (GILD)	2011-2012	100.46%
United Rentals (URI)	2011-2012	96.72%
TJX Companies (TJX)	2011-2012	95.18%
Charter Communications (CHTR)	2011-2012	95.09%