Regeneron Pharmaceuticals (REGN) had the highest return between 2010 and 2014 by a US stock in the S&P 500 (GSPC), returning 1,592.4%.

ASSET	YEARS	% RETURN
Regeneron Pharmaceuticals (REGN)	2010-2014	1,592.45%
Domino's Pizza Inc Common Stock (DPZ)	2010-2014	1,124.21%
Tesla (TSLA)	2010-2014	1,070.55%
United Rentals (URI)	2010-2014	928.33%
Expedia (EXPE)	2010-2014	757.42%
Incyte (INCY)	2010-2014	692.95%
Chipotle Mexican Grill (CMG)	2010-2014	663.96%
Ulta Beauty (ULTA)	2010-2014	572.23%
DexCom (DXCM)	2010-2014	570.52%
Biogen (BIIB)	2010-2014	528.96%
Tractor Supply (TSCO)	2010-2014	517.23%
Netflix (NFLX)	2010-2014	515.29%
Constellation Brands Inc Class A (STZ)	2010-2014	512.8%
Corpay (CPAY)	2010-2014	494.84%
Axon Enterprise (AXON)	2010-2014	493.72%
Transdigm (TDG)	2010-2014	493.43%
Broadcom (AVGO)	2010-2014	489.43%
NXP Semiconductors (NXPI)	2010-2014	487.69%
Old Dominion Freight Line (ODFL)	2010-2014	469.03%
Monster Beverage (MNST)	2010-2014	460.54%
Generac (GNRC)	2010-2014	445.88%
Tyler Technologies (TYL)	2010-2014	445.84%
United Airlines (UAL)	2010-2014	414.93%
Booking (BKNG)	2010-2014	412.87%
Skyworks Solutions (SWKS)	2010-2014	406.67%