AngloGold Ashanti (AU) had the highest return between 1998 and 2008 by a US stock, returning 11,570,550%.

ASSET	YEARS	% RETURN
AngloGold Ashanti (AU)	1998-2008	11,570,550%
Future Fintech (FTFT)	1998-2008	7,999,900%
InterContinental Hotels Group PLC ADR (IHG)	1998-2008	5,519,600%
India Globalization Capital (IGC)	1998-2008	1,616,566.67%
National Grid PLC ADR (NGG)	1998-2008	1,018,952.94%
Natwest (NWG)	1998-2008	953,400%
Hirequest (HQI)	1998-2008	935,500%
Houston American Energy (HUSA)	1998-2008	875,802.7%
Northern Oil & Gas (NOG)	1998-2008	838,607.69%
Know Labs (KNW)	1998-2008	534,224.43%
NextTrip (NTRP)	1998-2008	159,900%
Ring Energy (REI)	1998-2008	146,566.67%
Ocean Power Technologies (OPTT)	1998-2008	74,233.33%
Perspective Therapeutics (CATX)	1998-2008	66,566.67%
Cemtrex (CETX)	1998-2008	37,588.18%
Flexible Solutions International (FSI)	1998-2008	37,464.71%
Inuvo (INUV)	1998-2008	21,718.18%
Monster Beverage (MNST)	1998-2008	14,606.32%
PharmaCyte Biotech (PMCB)	1998-2008	12,988.89%
NanoViricides (NNVC)	1998-2008	11,240%
OPTIMIZERx (OPRX)	1998-2008	9,836%
Companhia Siderurgica Nacional ADR (SID)	1998-2008	8,069.43%
First Majestic Silver (AG)	1998-2008	7,838.67%
Gyre Therapeutics (GYRE)	1998-2008	7,448.45%
TherapeuticsMD (TXMD)	1998-2008	7,439.95%