Monster Beverage (MNST) had the highest return between 2001 and 2006 by a US stock in the S&P 500 (GSPC), returning 6,969.8%.

ASSET	YEARS	% RETURN
Monster Beverage (MNST)	2001-2006	6,969.77%
Tractor Supply (TSCO)	2001-2006	2,003.67%
Hologic (HOLX)	2001-2006	1,701.14%
CarMax (KMX)	2001-2006	1,262%
CME (CME)	2001-2006	1,248.04%
Axon Enterprise (AXON)	2001-2006	1,204.65%
Cognizant Technology Solutions Corp Class A (CTSH)	2001-2006	1,169.42%
Tapestry (TPR)	2001-2006	1,100.62%
Deckers Outdoor (DECK)	2001-2006	1,098.92%
Apple (AAPL)	2001-2006	1,040.57%
Texas Pacific Land Trust (TPL)	2001-2006	861.91%
Old Dominion Freight Line (ODFL)	2001-2006	712.29%
Western Digital (WDC)	2001-2006	698.5%
F5 Networks (FFIV)	2001-2006	686.32%
Tyler Technologies (TYL)	2001-2006	675.72%
Freeport-McMoran Copper & Gold (FCX)	2001-2006	672.84%
Wynn Resorts (WYNN)	2001-2006	671.08%
Altria (MO)	2001-2006	640.34%
Global Payments (GPN)	2001-2006	530.94%
Nucor (NUE)	2001-2006	522.39%
Gilead Sciences (GILD)	2001-2006	522.06%
Autodesk (ADSK)	2001-2006	520.29%
Steel Dynamics (STLD)	2001-2006	499.69%
Intuitive Surgical (ISRG)	2001-2006	490.1%
Garmin (GRMN)	2001-2006	472.48%