Oncology Institute (TOI) had the highest return in April 2025 by a small-cap US stock, returning 101.6%.

ASSET	MONTH	% RETURN
Oncology Institute (TOI)	April 2025	101.63%
ThredUp (TDUP)	April 2025	87.08%
Rezolve AI Limited Ordinary Shares (RZLV)	April 2025	83.33%
SES AI (SES)	April 2025	74.56%
Nutex Health (NUTX)	April 2025	69.18%
American Battery Technology Company Common Stock (ABAT)	April 2025	66.02%
Forward Industries (FWDI)	April 2025	65.04%
Sutro Biopharma (STRO)	April 2025	61.39%
Lexicon Pharmaceuticals (LXRX)	April 2025	58.49%
Roma Green Finance Limited Ordinary Shares (ROMA)	April 2025	55.41%
CorMedix (CRMD)	April 2025	51.15%
Meiwu Technology (WNW)	April 2025	49.71%
Zenas BioPharma, Inc Common Stock (ZBIO)	April 2025	49.03%
Canopy Growth (CGC)	April 2025	48.39%
Yalla Group (YALA)	April 2025	46.93%
MMTEC (MTC)	April 2025	46.34%
XMax (XWIN)	April 2025	45.71%
United States Antimony (UAMY)	April 2025	45.25%
Compass Minerals International (CMP)	April 2025	44.67%
Upstream Bio (UPB)	April 2025	43.79%
Sellas Life Sciences (SLS)	April 2025	43.52%
MBX Biosciences, Inc Common Stock (MBX)	April 2025	43.5%
Editas Medicine (EDIT)	April 2025	43.48%
Keros Therapeutics (KROS)	April 2025	42.97%
Republic Airways (RJET)	April 2025	41.77%

Small-cap stocks are treated as having a market cap between $300M and $2B.