National Grid PLC ADR (NGG) had the highest return between 2004 and 2006 by a large-cap US stock, returning 1,344,788.2%.

ASSET	YEARS	% RETURN
National Grid PLC ADR (NGG)	2004-2006	1,344,788.24%
Monster Beverage (MNST)	2004-2006	3,100.34%
Banco Bradesco SA ADR (BBD)	2004-2006	920.01%
Tenaris SA ADR (TS)	2004-2006	714.54%
Apple (AAPL)	2004-2006	687.54%
CME (CME)	2004-2006	617.56%
Allegheny Technologies (ATI)	2004-2006	609.24%
Bancolombia SA ADR (CIB)	2004-2006	569.36%
WESCO International (WCC)	2004-2006	563.02%
Suzano Papel e Celulose SA ADR (SUZ)	2004-2006	511.16%
Intuitive Surgical (ISRG)	2004-2006	460.82%
Clean Harbors (CLH)	2004-2006	444.54%
Hologic (HOLX)	2004-2006	440.65%
Illumina (ILMN)	2004-2006	438.49%
CBRE Group Inc Class A (CBRE)	2004-2006	424.21%
ArcelorMittal SA ADR (MT)	2004-2006	418.82%
America Movil SAB de CV ADR (AMX)	2004-2006	413.93%
Cheniere Energy (LNG)	2004-2006	393.93%
Akamai Technologies (AKAM)	2004-2006	389.59%
Ambev SA ADR (ABEV)	2004-2006	371.25%
Vale SA ADR (VALE)	2004-2006	367.52%
Teck Resources Ltd Class B (TECK)	2004-2006	362.77%
Alphabet Inc Class A (GOOGL)	2004-2006	360.45%
Jones Lang LaSalle (JLL)	2004-2006	348.88%
Texas Pacific Land Trust (TPL)	2004-2006	340.96%

Large-cap stocks are treated as having a market cap of $10B+.