InterContinental Hotels Group PLC ADR (IHG) had the highest return between 1999 and 2009 by a US stock, returning 9,928,700%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	1999-2009	9,928,700%
QVC (QVCGA)	1999-2009	5,621,098.15%
Northern Oil & Gas (NOG)	1999-2009	3,819,246.15%
India Globalization Capital (IGC)	1999-2009	2,299,900%
Houston American Energy (HUSA)	1999-2009	1,598,586.28%
Cemtrex (CETX)	1999-2009	1,293,451.36%
National Grid PLC ADR (NGG)	1999-2009	1,161,476.47%
Know Labs (KNW)	1999-2009	1,068,548.85%
Hirequest (HQI)	1999-2009	935,500%
Natwest (NWG)	1999-2009	590,100%
Perspective Therapeutics (CATX)	1999-2009	296,566.67%
Ring Energy (REI)	1999-2009	133,233.33%
Ocean Power Technologies (OPTT)	1999-2009	100,011.11%
Gyre Therapeutics (GYRE)	1999-2009	44,215.31%
Flexible Solutions International (FSI)	1999-2009	27,458.82%
Companhia Siderurgica Nacional ADR (SID)	1999-2009	22,649.27%
Future Fintech (FTFT)	1999-2009	20,500%
ImmunoPrecise Antibodies (HYFT)	1999-2009	20,471.43%
TherapeuticsMD (TXMD)	1999-2009	19,503.88%
First Majestic Silver (AG)	1999-2009	17,180.89%
Weatherford International (WFRD)	1999-2009	12,100%
NanoViricides (NNVC)	1999-2009	11,800%
Broadwind Energy (BWEN)	1999-2009	9,608.39%
Gerdau SA ADR (GGB)	1999-2009	7,901.78%
Monster Beverage (MNST)	1999-2009	5,624.51%