QXO (QXO) had the highest return between 2010 and 2017 by a large-cap US stock, returning 4,956,500%.

ASSET	YEARS	% RETURN
QXO (QXO)	2010-2017	4,956,500%
Ferguson (FERG)	2010-2017	202,076.45%
Neurocrine Biosciences (NBIX)	2010-2017	2,701.08%
Domino's Pizza Inc Common Stock (DPZ)	2010-2017	2,436.62%
Netflix (NFLX)	2010-2017	2,320.25%
Cheniere Energy (LNG)	2010-2017	2,053.6%
XPO Logistics (XPO)	2010-2017	1,661%
United Rentals (URI)	2010-2017	1,632.97%
Tesla (TSLA)	2010-2017	1,538.64%
Broadcom (AVGO)	2010-2017	1,477.12%
Regeneron Pharmaceuticals (REGN)	2010-2017	1,450.99%
Texas Pacific Land Trust (TPL)	2010-2017	1,436.5%
Constellation Brands Inc Class A (STZ)	2010-2017	1,366.97%
Ulta Beauty (ULTA)	2010-2017	1,076.09%
NVIDIA (NVDA)	2010-2017	1,027.6%
Take-Two Interactive Software (TTWO)	2010-2017	978.39%
Incyte (INCY)	2010-2017	927.22%
NetEase (NTES)	2010-2017	900.82%
Genmab A-S (GMAB)	2010-2017	892.57%
Transdigm (TDG)	2010-2017	885.71%
Monster Beverage (MNST)	2010-2017	882.28%
Old Dominion Freight Line (ODFL)	2010-2017	867.96%
Charter Communications (CHTR)	2010-2017	859.89%
Centene (CNC)	2010-2017	842.8%
NXP Semiconductors (NXPI)	2010-2017	800.69%

Large-cap stocks are treated as having a market cap of $10B+.