MDxHealth SA ADR (MDXH) has had the highest return since 2021 by a US stock, returning 297,172.7%.

ASSET	% RETURN
MDxHealth SA ADR (MDXH)	297,172.73%
BioNexus Gene Lab Corp Common stock (BGLC)	169,465.22%
DevvStream Corp Common Stock (DEVS)	137,900%
Applied Digital (APLD)	85,073.33%
Sapiens International (SPNS)	49,706.13%
Castellum (CTM)	23,990.91%
Regencell Bioscience (RGC)	13,015.9%
Heart Test Laboratories Inc Common Stock (HSCS)	9,752.94%
LMF Acquisition Opportunities (ICU)	6,047.96%
Azitra (AZTR)	5,326.79%
QMMM Holdings Limited Ordinary Shares (QMMM)	3,880%
Terrestrial Energy (IMSRW)	3,785.71%
Celestica (CLS)	3,441.1%
Guardforce AI (GFAI)	3,167.79%
Santech (STEC)	3,028%
Foremost Lithium Resource & Technology Ltd Common stock (FMST)	2,958.98%
Alpha Metallurgical Resources (AMR)	2,043.1%
Sezzle (SEZL)	1,911.66%
Power Solutions International, Inc Common Stock (PSIX)	1,855.73%
Comfort Systems USA (FIX)	1,785.77%
Build-A-Bear Workshop (BBW)	1,663.58%
Vista Oil Gas ADR (VIST)	1,647.49%
Euroseas (ESEA)	1,514.66%
Sterling Construction (STRL)	1,493.25%
Weatherford International (WFRD)	1,437.31%