Brera Holdings PLC Class B Ordinary Shares (BREA) has had the highest return since 2020 by a micro-cap US stock, returning 1,328,900%.

ASSET	% RETURN
Brera Holdings PLC Class B Ordinary Shares (BREA)	1,328,900%
Integra Resources (ITRG)	298,233.33%
MDxHealth SA ADR (MDXH)	258,990.91%
BioNexus Gene Lab Corp Common stock (BGLC)	130,143.9%
Foremost Lithium Resource & Technology Ltd Common stock (FMST)	7,392.45%
Azitra (AZTR)	2,757.14%
Zivo Bioscience (ZIVO)	1,743.43%
CPI Card (PMTS)	1,634.44%
Energy Services Of America (ESOA)	1,103.29%
Castellum (CTM)	974.77%
Aeluma, Inc Common Stock (ALMU)	843.5%
FitLife Brands, Inc Common Stock (FTLF)	837.73%
Empire Petroleum (EP)	745.42%
RCM Technologies (RCMT)	737.01%
Oxbridge Re Holdings Equity Warrant (OXBRW)	676.94%
Comstock Holding Companies (CHCI)	635.15%
Kolibri Global Energy Inc Common stock (KGEI)	611.25%
Smith-Midland (SMID)	591.31%
Performant Healthcare (PHLT)	573.45%
Electrovaya Inc Common Shares (ELVA)	565.26%
BTCS (BTCS)	539.04%
Optex Systems Holdings, Inc Common Stock (OPXS)	481.68%
American Battery Technology Company Common Stock (ABAT)	477.08%
Universal Security Instruments (UUU)	473.33%
Core Molding Technologies (CMT)	433.85%

Micro-cap stocks are treated as having a market cap of <= $300M.