American International (AIG) had the lowest return between 2007 and 2008 by a large-cap US stock, returning -97.7%.

ASSET	YEARS	% RETURN
American International (AIG)	2007-2008	-97.75%
Celsius (CELH)	2007-2008	-96.67%
Las Vegas Sands (LVS)	2007-2008	-93.52%
Builders FirstSource (BLDR)	2007-2008	-91.5%
Primo Brands (PRMB)	2007-2008	-91.04%
Cheniere Energy (LNG)	2007-2008	-90.27%
Advanced Micro Devices (AMD)	2007-2008	-89.24%
CBRE Group Inc Class A (CBRE)	2007-2008	-87.07%
Citigroup (C)	2007-2008	-86.7%
Teck Resources Ltd Class B (TECK)	2007-2008	-85.84%
Lennar (LEN.B)	2007-2008	-85.75%
KKR (KKR)	2007-2008	-85.41%
AerCap (AER)	2007-2008	-84.9%
Tenet Healthcare (THC)	2007-2008	-83.62%
Lennar (LEN)	2007-2008	-82.26%
Coeur Mining (CDE)	2007-2008	-82.15%
Seagate Technology (STX)	2007-2008	-81.89%
Micron Technology (MU)	2007-2008	-81.33%
Barclays PLC ADR (BCS)	2007-2008	-81.16%
Hartford Financial Services (HIG)	2007-2008	-80.69%
Lloyds Banking Group PLC ADR (LYG)	2007-2008	-80.42%
EXACT Sciences (EXAS)	2007-2008	-80%
Blackstone (BX)	2007-2008	-79.91%
Entegris (ENTG)	2007-2008	-79.91%
Orix Corp Ads (IX)	2007-2008	-79.84%

Large-cap stocks are treated as having a market cap of $10B+.