Deutsche Bank (DB) had the lowest return between 2010 and 2019 by a large-cap US stock, returning -86.9%.

ASSET	YEARS	% RETURN
Deutsche Bank (DB)	2010-2019	-86.87%
ArcelorMittal SA ADR (MT)	2010-2019	-86.03%
BitMine Immersion Technologies (BMNR)	2010-2019	-85%
Summit Therapeutics (SMMT)	2010-2019	-83.84%
Ovintiv (OVV)	2010-2019	-82.65%
Teva Pharma Industries Ltd ADR (TEVA)	2010-2019	-79%
Kinross Gold (KGC)	2010-2019	-74.12%
Cameco (CCJ)	2010-2019	-67.59%
PG&E (PCG)	2010-2019	-67.44%
YPF Sociedad Anonima (YPF)	2010-2019	-67.17%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2010-2019	-61.69%
Devon Energy (DVN)	2010-2019	-60.88%
Bloom Energy (BE)	2010-2019	-60.05%
Cemex SAB de CV ADR (CX)	2010-2019	-59.94%
GameStop (GME)	2010-2019	-59.08%
First Solar (FSLR)	2010-2019	-58.85%
Freeport-McMoran Copper & Gold (FCX)	2010-2019	-58.81%
Mosaic (MOS)	2010-2019	-57.94%
Nokia (NOK)	2010-2019	-57.67%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2010-2019	-55.26%
Permian Resources (PR)	2010-2019	-53.8%
Telefonica SA ADR (TEF)	2010-2019	-52.95%
EQT (EQT)	2010-2019	-51.53%
Cenovus Energy (CVE)	2010-2019	-49.91%
Banco Bilbao Viscaya Argentaria SA ADR (BBVA)	2010-2019	-48.37%

Large-cap stocks are treated as having a market cap of $10B+.