CJ McCollum has put up his most career points per game versus the Pistons, with 22.5 per game.

cj mccollum highest career ppg by opponent

OPP	PPG	GP	MPG	RPG	APG	SPG	BPG	TPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	MIN	PTS	REB	AST	STL	BLK	TOV	PF	+/-
Pistons	22.5	15	35.2	3.6	5.1	0.8	0.7	2.3	8.9	18.7	47.7	2.6	6.8	38.2	2.0	2.3	85.7	528	337	54	76	12	10	34	32	+14
Grizzlies	22.0	34	34.0	3.7	3.8	1.0	0.3	2.2	8.1	16.8	48.3	2.9	6.8	42.6	2.9	3.7	78.6	1,155	749	125	129	35	11	76	86	-11
Trail Blazers	21.2	9	33.1	4.1	6.9	1.4	0.6	2.4	8.0	17.3	46.2	3.3	8.2	40.5	1.9	2.9	65.4	297	191	37	62	13	5	22	9	+127
Celtics	21.2	20	34.7	3.6	3.9	0.9	0.8	1.7	8.1	18.2	44.5	2.8	7.3	37.9	2.2	3.1	72.1	694	423	72	77	17	15	34	51	-36
Hawks	21.1	17	32.6	4.7	4.4	1.0	0.6	1.5	8.4	18.4	45.7	2.3	6.5	35.1	1.9	2.6	75.0	554	358	80	75	17	11	25	32	+16
Kings	20.9	31	32.6	3.5	4.2	1.3	0.5	2.0	8.3	17.1	48.2	2.5	6.4	38.7	1.9	2.6	75.0	1,009	649	109	130	41	17	63	72	+131
Suns	20.8	33	32.6	3.7	4.7	1.0	0.6	1.7	8.1	16.5	49.0	2.5	6.2	40.7	2.2	2.6	84.9	1,076	688	122	156	32	20	56	73	+98
Pacers	20.8	17	32.5	4.1	3.9	0.7	0.5	1.8	7.9	17.1	46.2	3.4	7.2	46.7	1.6	1.8	90.3	552	353	70	66	12	9	30	37	+54
Bulls	20.7	16	32.4	3.7	4.4	0.5	0.4	1.9	7.9	16.9	46.9	2.5	6.6	37.7	2.3	2.6	90.2	519	331	59	71	8	6	31	23	+45
Magic	20.5	21	31.9	3.0	3.5	1.0	0.3	2.3	7.5	16.2	46.2	2.2	6.1	36.7	3.3	3.7	88.5	670	430	64	74	21	7	48	46	+81
76ers	20.1	17	33.7	3.9	3.3	1.2	0.2	2.2	7.2	16.8	42.7	2.6	6.6	39.3	3.2	3.6	88.5	572	342	66	56	20	3	37	33	+38
Spurs	20.0	35	30.6	3.9	3.4	0.8	0.5	1.7	7.8	17.2	45.6	2.2	5.8	37.7	2.2	2.7	81.7	1,072	701	137	118	28	18	58	55	+74
Bucks	19.8	18	31.2	3.1	4.5	1.2	0.4	1.8	7.4	16.3	45.6	2.4	6.3	37.7	2.6	3.2	79.3	562	357	55	81	22	8	33	38	-109
Jazz	19.6	35	32.2	3.8	3.0	0.8	0.3	1.9	7.7	17.2	44.4	2.3	5.5	42.2	2.0	2.7	74.5	1,128	687	133	106	29	12	68	83	+30
Hornets	19.5	18	32.6	3.3	3.8	0.9	0.3	1.8	7.3	16.8	43.6	2.7	6.4	41.4	2.2	2.6	83.0	587	351	60	68	16	6	33	36	+60
Rockets	19.5	34	33.4	3.8	4.0	1.0	0.4	1.8	7.4	16.3	45.6	2.5	6.7	37.3	2.1	2.8	76.6	1,136	663	130	137	35	15	60	61	+110
Timberwolves	19.2	29	30.7	3.0	3.3	1.2	0.6	1.9	7.2	15.2	47.2	2.3	5.1	45.6	2.5	3.1	80.2	891	557	87	95	34	17	55	65	+138
Warriors	19.2	32	31.6	3.8	3.2	0.8	0.4	1.8	7.2	16.5	43.5	2.6	6.6	39.5	2.2	2.7	80.5	1,011	613	120	103	27	12	59	60	-80
Thunder	19.2	32	32.6	4.2	3.7	0.6	0.3	2.1	7.1	16.8	42.2	2.7	6.7	40.5	2.3	2.5	88.9	1,043	613	134	118	18	11	67	64	+46
Nets	19.1	18	32.4	4.2	4.1	0.8	0.6	1.9	7.3	16.0	45.5	2.6	5.9	43.4	2.0	2.6	78.3	583	344	75	74	15	10	35	38	+162
Raptors	18.9	21	30.9	3.9	3.7	1.0	0.4	1.4	7.1	14.8	48.1	2.9	6.2	46.6	1.8	2.3	77.6	649	397	81	78	20	9	29	43	-13
Wizards	18.5	18	29.2	3.1	2.9	0.6	0.2	1.4	7.1	14.7	48.1	2.4	5.5	43.4	2.0	2.3	85.7	526	333	56	53	11	4	26	41	+73
Heat	18.4	19	32.1	3.3	3.9	0.8	0.4	2.4	7.1	16.3	43.7	3.1	7.6	40.7	1.1	1.6	70.0	609	350	62	75	15	7	45	42	-28
Lakers	18.4	38	31.3	3.6	4.4	0.9	0.3	1.4	7.1	16.1	43.9	2.4	6.3	37.5	1.9	2.4	80.0	1,188	698	135	167	35	10	55	82	+48
Clippers	18.3	35	31.9	3.9	3.3	1.0	0.3	1.6	7.0	15.6	44.9	2.3	5.7	40.8	1.9	2.4	79.8	1,118	639	136	117	36	9	55	85	-27