I don't have anything for this season, but Donovan Mitchell had the highest plus/minus for the Cavaliers in 2025-26, at +370.

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Regular season
2025-26 season

	NAME	+/-	SEASON	TM	GP	MPG	PPG	RPG	APG	SPG	BPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TPG	MIN	PTS	REB	AST	STL	BLK	TOV	PF
1	Donovan Mitchell D. Mitchell	+370	2025-26	CLE	70	33.5	27.9	4.5	5.7	1.5	0.3	9.7	20.0	48.3	3.2	8.8	36.4	5.3	6.1	86.5	61.3	0.7	3.8	2.8	2,342	1,952	316	398	104	20	198	163
2	Sam Merrill S. Merrill	+242	2025-26	CLE	52	26.5	12.8	2.6	2.4	0.6	0.1	4.3	9.3	46.1	3.0	7.2	42.1	1.1	1.3	85.5	64.4	0.5	2.0	0.8	1,377	663	133	125	33	7	42	127
3	Evan Mobley E. Mobley	+224	2025-26	CLE	65	31.9	18.2	9.0	3.6	0.7	1.7	7.2	13.2	54.6	1.0	3.2	29.7	2.8	4.6	60.6	59.6	2.4	6.6	1.9	2,074	1,180	586	234	48	113	122	159
4	Jarrett Allen J. Allen	+213	2025-26	CLE	56	27.1	15.4	8.5	1.8	1.0	0.8	6.0	9.4	63.8	0.0	0.2	10.0	3.3	4.7	70.9	66.9	2.6	5.9	1.3	1,519	860	476	100	55	47	75	95
5	Dean Wade D. Wade	+151	2025-26	CLE	59	22.3	5.8	4.2	1.5	0.7	0.4	2.1	4.7	43.9	1.2	3.3	36.2	0.5	0.6	71.1	58.0	0.9	3.3	0.3	1,318	342	247	88	44	23	16	90
6	Jaylon Tyson J. Tyson	+110	2025-26	CLE	66	26.9	13.2	5.1	2.2	0.8	0.4	5.0	10.2	49.3	2.0	4.5	44.6	1.2	1.6	73.8	60.8	1.8	3.3	1.5	1,777	872	338	147	54	28	99	164
7	Craig Porter Jr. C. Porter Jr.	+103	2025-26	CLE	64	17.9	4.5	3.4	3.2	0.9	0.6	1.8	4.0	45.0	0.5	1.5	35.5	0.4	0.6	60.0	52.4	1.3	2.1	0.9	1,148	289	220	205	57	38	59	70
8	James Harden J. Harden	+79	2025-26	CLE	26	33.8	20.5	4.8	7.7	0.8	0.5	6.3	13.5	46.6	3.1	7.1	43.5	4.8	5.8	84.0	63.9	0.5	4.3	3.2	879	534	124	199	22	12	83	54
9	Keon Ellis K. Ellis	+68	2025-26	CLE	29	24.8	8.3	2.8	1.6	1.3	0.8	3.0	6.0	49.1	1.3	3.7	35.5	1.1	1.3	81.6	62.9	0.8	2.0	0.7	720	241	80	46	37	24	20	65
10	Nae'Qwan Tomlin N. Tomlin	+60	2025-26	CLE	64	15.7	5.8	2.9	0.8	0.6	0.5	2.3	4.9	47.8	0.4	1.8	23.5	0.7	1.0	77.0	54.9	1.3	1.6	0.5	1,004	374	186	53	41	34	29	125
11	Tristan Enaruna T. Enaruna	+43	2025-26	CLE	9	9.4	4.1	1.6	0.8	0.6	0.0	1.6	3.1	50.0	0.3	1.1	30.0	0.7	0.9	75.0	58.7	0.8	0.8	0.3	85	37	14	7	5	0	3	3
12	Thomas Bryant T. Bryant	+39	2025-26	CLE	60	12.2	6.2	3.4	0.6	0.3	0.4	2.3	4.5	50.6	0.8	2.2	35.9	0.9	1.1	80.3	62.5	1.0	2.4	0.5	732	370	205	33	18	26	28	75
13	Lonzo Ball L. Ball	+32	2025-26	CLE	35	20.8	4.6	4.0	3.9	1.3	0.3	1.5	5.0	30.1	1.1	4.2	27.2	0.4	0.6	66.7	43.2	0.7	3.3	1.5	728	160	140	136	45	9	52	46
14	Olivier Sarr O. Sarr	+26	2025-26	CLE	4	9.8	3.5	2.8	1.3	0.5	0.8	1.3	1.8	71.4	0.5	0.8	66.7	0.5	1.3	40.0	76.1	0.5	2.3	0.5	39	14	11	5	2	3	2	9
15	Dennis Schröder D. Schröder	+21	2025-26	CLE	30	21.4	8.2	2.3	4.3	0.8	0.2	2.8	6.9	40.1	0.6	2.1	29.0	2.1	2.4	86.1	51.5	0.4	1.9	1.5	641	246	68	130	23	5	45	43
16	Riley Minix R. Minix	+19	2025-26	CLE	6	8.3	4.3	0.7	0.7	0.2	0.2	1.7	2.8	58.8	0.5	1.5	33.3	0.5	0.5	100.0	71.0	0.2	0.5	0.5	50	26	4	4	1	1	3	4
17	Chris Livingston C. Livingston	+8	2025-26	CLE	3	5.7	3.0	1.0	0.3	0.3	0.0	1.3	2.3	57.1	0.0	1.0	0.0	0.3	0.3	100.0	60.5	0.0	1.0	0.0	17	9	3	1	1	0	0	4
18	Max Strus M. Strus	-3	2025-26	CLE	12	24.0	11.2	5.4	2.0	0.3	0.0	3.9	8.8	44.3	2.8	6.8	40.2	0.6	0.8	77.8	60.9	0.8	4.7	0.8	288	134	65	24	3	0	9	34
19	Darius Brown D. Brown	-4	2025-26	CLE	1	3.0	0.0	1.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0		0.0	0.0		0.0	0.0	1.0	0.0	3	0	1	0	0	0	0	0
20	Tyrese Proctor T. Proctor	-7	2025-26	CLE	50	10.9	5.4	1.3	1.5	0.5	0.0	1.9	4.5	41.3	0.9	2.6	35.1	0.8	0.9	88.9	55.6	0.2	1.1	0.8	545	272	64	74	25	0	40	59
21	Larry Nance Jr. L. Nance Jr.	-17	2025-26	CLE	35	12.8	3.7	2.7	1.0	0.6	0.2	1.5	3.5	41.9	0.6	1.8	33.3	0.2	0.4	46.2	50.5	0.8	1.8	0.6	449	131	93	34	21	6	20	55
22	De'Andre Hunter D. Hunter	-20	2025-26	CLE	43	26.2	14.0	4.2	2.1	0.7	0.1	4.7	11.2	42.3	1.7	5.5	30.8	2.8	3.2	86.9	55.3	0.7	3.6	1.7	1,125	600	182	89	30	6	71	107
23	Luke Travers L. Travers	-32	2025-26	CLE	12	8.6	2.3	2.0	0.8	0.6	0.3	0.8	3.0	25.0	0.1	1.3	6.3	0.8	0.8	100.0	35.0	0.8	1.3	0.3	103	28	24	9	7	4	3	6
24	Darius Garland D. Garland	-40	2025-26	CLE	26	30.5	18.0	2.4	6.9	0.8	0.1	6.5	14.5	45.1	2.3	6.3	36.0	2.6	3.0	86.1	56.7	0.5	2.0	2.8	792	467	63	180	21	3	73	48