Since 2021-22, DeMar DeRozan has dropped his most points in a regular-season or postseason game against the Celtics on November 4, 2022, with 46 points.
| NAME | PTS | DATE | TM | OPP | MIN | REB | AST | STL | BLK | FGM | FGA | FG% | 3PM | 3PA | 3P% | FTM | FTA | FT% | TS% | OREB | DREB | TOV | PF | +/- | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | D. DeRozan | 46 | 11/4/2022 |  CHI | @ |  BOS | 36 | 3 | 5 | 2 | 1 | 13 | 23 | 56.5 | 0 | 3 | 0.0 | 20 | 22 | 90.9 | 70.4 | 0 | 3 | 2 | 3 | +10 |
| 2 | | D. DeRozan | 37 | 11/1/2021 | CHI | @ | BOS | 34 | 6 | 2 | 1 | 1 | 15 | 20 | 75.0 | 3 | 4 | 75.0 | 4 | 5 | 80.0 | 83.3 | 0 | 6 | 1 | 3 | +4 |
| 3 | | D. DeRozan | 28 | 3/23/2024 | CHI | vs | BOS | 42 | 6 | 9 | 0 | 1 | 12 | 19 | 63.2 | 0 | 1 | 0.0 | 4 | 4 | 100.0 | 67.4 | 0 | 6 | 2 | 1 | -3 |
| 4 | | D. DeRozan | 28 | 11/21/2022 | CHI | vs | BOS | 35 | 8 | 4 | 1 | 0 | 11 | 24 | 45.8 | 3 | 3 | 100.0 | 3 | 3 | 100.0 | 55.3 | 0 | 8 | 2 | 3 | +20 |
| 5 | | D. DeRozan | 25 | 10/24/2022 | CHI | vs | BOS | 33 | 5 | 5 | 1 | 0 | 10 | 17 | 58.8 | 0 | 0 | 5 | 5 | 100.0 | 65.1 | 0 | 5 | 3 | 1 | +1 | |
| 6 |  | D. DeRozan | 24 | 1/10/2025 |  SAC | @ | BOS | 40 | 4 | 9 | 1 | 1 | 9 | 26 | 34.6 | 2 | 5 | 40.0 | 4 | 5 | 80.0 | 42.6 | 0 | 4 | 0 | 2 | +15 |
| 7 | | D. DeRozan | 23 | 1/15/2022 | CHI | @ | BOS | 37 | 8 | 7 | 0 | 1 | 7 | 20 | 35.0 | 0 | 0 | 9 | 9 | 100.0 | 48.0 | 1 | 7 | 2 | 1 | +11 | |
| 8 | | D. DeRozan | 20 | 3/24/2025 | SAC | vs | BOS | 38 | 3 | 10 | 0 | 1 | 9 | 24 | 37.5 | 0 | 4 | 0.0 | 2 | 2 | 100.0 | 40.2 | 2 | 1 | 1 | 3 | -11 |
| 9 | | D. DeRozan | 19 | 2/22/2024 | CHI | vs | BOS | 36 | 4 | 5 | 1 | 0 | 7 | 17 | 41.2 | 1 | 3 | 33.3 | 4 | 4 | 100.0 | 50.6 | 1 | 3 | 2 | 2 | -5 |
| 10 | | D. DeRozan | 19 | 11/28/2023 | CHI | @ | BOS | 26 | 2 | 6 | 0 | 0 | 7 | 14 | 50.0 | 1 | 3 | 33.3 | 4 | 4 | 100.0 | 60.3 | 0 | 2 | 2 | 2 | -20 |
| 11 | | D. DeRozan | 16 | 4/6/2022 | CHI | vs | BOS | 33 | 2 | 5 | 2 | 0 | 6 | 16 | 37.5 | 1 | 1 | 100.0 | 3 | 4 | 75.0 | 45.0 | 0 | 2 | 2 | 2 | -18 |
| 12 | | D. DeRozan | 13 | 1/9/2023 | CHI | @ | BOS | 23 | 3 | 3 | 1 | 0 | 6 | 9 | 66.7 | 0 | 0 | 1 | 1 | 100.0 | 68.9 | 0 | 3 | 2 | 1 | -12 |
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