The Memphis Grizzlies have the highest point differential by a team in a game, with a 73 point differential against the Thunder on December 2, 2021.

largest point differential in an nba game

Interpreted as:

largest point differential in an NBA regular-season game

TEAM	DIFF	DATE	TM		OPP	RESULT	MIN	PTS	REB	AST	STL	BLK	TOV	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	PF
Memphis Grizzlies	73	12/2/2021	MEM	vs	OKC	W 152-79	240	152	53	41	16	9	10	60	96	62.5	19	36	52.8	13	18	72.2	15
Cleveland Cavaliers	68	12/17/1991	CLE	vs	MIA	W 148-80	240	148	59	39	11	5	9	59	103	57.3	6	11	54.5	24	29	82.8	16
Indiana Pacers	65	2/27/1998	IND	vs	POR	W 124-59	240	124	48	35	16	5	17	49	77	63.6	9	15	60.0	17	22	77.3	21
Los Angeles Lakers	63	3/19/1972	LAL	vs	GSW	W 162-99	240	162	73	43				69	113	61.1				24	32	75.0	21
Oklahoma City Thunder	62	1/11/2024	OKC	vs	POR	W 139-77	240	139	59	41	6	8	12	53	93	57.0	14	35	40.0	19	22	86.4	10
Golden State Warriors	62	11/2/1991	GSW	vs	SAC	W 153-91	240	153	60	38	15	4	22	58	101	57.4	1	5	20.0	36	40	90.0	15
Syracuse Nationals	62	12/25/1960	SYR	vs	NYK	W 162-100	240	162						65						32	37	86.5	28
Charlotte Hornets	61	3/22/2018	CHA	vs	MEM	W 140-79	240	140	53	25	10	4	8	49	92	53.3	19	40	47.5	23	27	85.2	17
Miami Heat	60	3/29/2024	MIA	vs	POR	W 142-82	240	142	44	41	17	4	8	54	92	58.7	21	39	53.8	13	18	72.2	13
Milwaukee Bucks	59	12/26/1978	MIL	vs	DET	W 143-84	240	143	54	53	17	11	21	65	107	60.7				13	17	76.5	12
Golden State Warriors	59	3/19/1977	GSW	vs	IND	W 150-91	240	150	71	39	13	10	20	65	122	53.3				20	26	76.9	20
Sacramento Kings	58	12/29/1992	SAC	vs	DAL	W 139-81	240	139	57	40	14	8	18	50	97	51.5	6	17	35.3	33	37	89.2	21
Milwaukee Bucks	58	12/15/1985	MIL	vs	SAC	W 140-82	240	140	38	34	13	2	19	54	81	66.7	2	3	66.7	30	36	83.3	22
Indiana Pacers	57	5/1/2021	IND	@	OKC	W 152-95	240	152	53	41	7	11	17	57	87	65.5	21	33	63.6	17	22	77.3	22
Golden State Warriors	56	4/9/2023	GSW	@	POR	W 157-101	240	157	58	47	13	6	15	58	96	60.4	27	49	55.1	14	16	87.5	18
Boston Celtics	56	12/8/2018	BOS	@	CHI	W 133-77	240	133	54	34	10	4	7	50	93	53.8	22	43	51.2	11	15	73.3	14
Seattle SuperSonics	56	3/6/1993	SEA	vs	PHI	W 149-93	240	149	48	38	13	8	13	64	102	62.7	9	13	69.2	12	17	70.6	19
Sacramento Kings	56	1/2/1993	SAC	vs	PHI	W 154-98	240	154	46	38	22	9	13	61	106	57.5	9	17	52.9	23	31	74.2	25
Seattle SuperSonics	56	12/6/1986	SEA	@	HOU	W 136-80	240	136	55	26	14	7	19	52	91	57.1	1	3	33.3	31	33	93.9	21
Milwaukee Bucks	56	3/14/1979	MIL	vs	NOJ	W 158-102	240	158	51	45	21	7		69	106	65.1				20	22	90.9	21
Chicago Bulls	56	2/20/1976	CHI	vs	POR	W 130-74	240	130	60	29	14	3		56	111	50.5				18	27	66.7	19
Los Angeles Lakers	56	11/12/1966	LAL	vs	DET	W 144-88	240	144	75	32				53	97	54.6				38	44	86.4	19
Los Angeles Lakers	55	1/11/2011	LAL	vs	CLE	W 112-57	240	112	53	25	11	7	12	46	86	53.5	10	20	50.0	10	15	66.7	14
Phoenix Suns	55	4/17/1989	PHX	vs	SAC	W 140-85	240	140	48	33	16	4	13	51	90	56.7	6	9	66.7	32	41	78.0	19
Philadelphia 76ers	54	11/2/1970	PHI	vs	CLE	W 141-87	240	141	54	35				52	92	56.5				37	53	69.8	23