Lou Williams had his most career points per game against the Lakers, with 16.9 per game.

lou williams highest career ppg by opponent

OPP	PPG	GP	MPG	RPG	APG	SPG	BPG	TPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	MIN	PTS	REB	AST	STL	BLK	TOV	PF	+/-
Lakers	16.9	25	26.2	2.6	4.3	1.0	0.0	1.7	5.7	12.0	47.2	1.8	4.4	40.5	3.7	4.3	86.9	656	422	65	108	25	1	42	28	+131
Warriors	16.7	37	25.7	2.6	3.6	0.9	0.2	2.0	5.1	11.4	44.7	1.5	3.9	38.4	5.1	5.7	89.0	950	619	98	134	34	9	75	54	-85
Nuggets	16.3	30	26.6	2.5	4.0	0.8	0.3	1.9	5.0	11.5	43.3	1.5	4.4	34.8	4.8	6.1	79.1	799	488	76	121	25	8	58	51	+7
76ers	16.1	21	25.5	2.4	3.5	1.4	0.1	2.2	5.0	12.0	41.3	1.8	5.2	33.6	4.5	5.5	81.0	536	339	51	74	30	2	46	18	+9
Rockets	16.1	31	26.8	2.6	4.0	1.1	0.2	1.8	5.5	11.8	46.4	1.4	3.6	37.8	3.8	4.5	83.0	832	499	82	124	33	6	55	40	+8
Suns	16.0	40	23.9	2.6	3.2	0.7	0.2	1.9	5.4	11.0	48.6	1.9	4.1	45.7	3.4	4.2	79.9	958	638	102	128	29	7	75	59	+59
Timberwolves	15.6	33	26.5	2.7	4.5	0.7	0.2	1.9	4.9	11.6	42.4	1.3	4.0	32.3	4.5	5.0	89.6	876	516	88	148	23	6	63	55	-6
Kings	15.6	37	25.0	2.2	3.4	1.2	0.3	2.0	4.9	12.0	40.7	1.8	4.9	36.5	4.0	4.6	86.0	926	576	82	127	44	12	73	47	+129
Jazz	15.5	40	25.2	2.7	3.4	1.2	0.2	1.9	4.9	12.1	40.6	1.2	3.5	34.8	4.4	5.3	83.5	1,007	620	107	137	48	7	75	50	-44
Cavaliers	14.7	42	24.8	2.3	3.5	0.7	0.1	1.7	4.9	10.7	46.0	1.2	3.3	36.0	3.6	4.2	85.4	1,043	616	97	146	30	6	70	57	+74
Grizzlies	14.6	40	24.0	1.9	3.4	1.0	0.2	1.8	4.6	10.8	42.5	1.6	4.0	39.1	3.9	4.4	88.6	961	585	77	135	41	7	71	44	+78
Thunder	14.4	34	23.8	1.8	3.3	1.2	0.0	1.9	4.4	11.4	39.0	1.6	4.3	38.4	3.9	4.6	84.2	810	491	61	111	40	1	66	32	-93
Celtics	14.3	42	25.8	2.2	3.7	0.9	0.2	1.9	4.7	11.1	42.8	1.2	3.6	32.7	3.7	4.7	78.2	1,082	601	94	155	37	9	80	61	-24
Bucks	14.2	37	24.9	2.3	3.4	0.9	0.1	2.1	4.4	10.9	40.6	1.3	3.8	35.3	4.1	5.0	81.1	921	527	85	127	34	3	79	57	+87
Magic	14.2	43	24.2	2.4	3.0	0.8	0.1	1.5	4.6	10.9	42.4	1.3	3.4	37.7	3.7	4.3	86.9	1,040	610	103	130	34	3	65	52	+15
Wizards	13.8	49	22.7	1.7	2.8	0.8	0.1	1.6	4.5	9.9	45.5	1.4	3.6	39.9	3.3	3.8	87.6	1,111	675	83	138	41	7	78	68	-20
Knicks	13.5	42	22.6	2.2	3.6	0.6	0.1	1.7	4.1	10.0	41.3	1.3	3.7	35.7	3.9	4.5	86.4	950	567	91	152	27	5	70	47	+88
Hawks	13.4	34	23.5	2.1	3.7	0.8	0.2	1.4	4.4	10.6	40.9	1.1	3.4	33.3	3.6	4.2	86.0	800	457	73	127	27	7	49	46	+75
Pistons	13.3	41	24.4	2.2	3.4	0.6	0.2	1.7	4.4	9.9	44.7	1.3	3.3	39.6	3.1	3.9	81.1	999	546	92	139	23	10	68	51	+124
Pelicans	13.2	37	24.2	2.4	3.6	0.8	0.2	1.7	4.4	11.1	39.5	1.1	3.7	28.3	3.4	4.3	80.4	897	490	87	134	29	6	63	43	+24
Hornets	13.1	44	22.5	2.2	3.4	0.8	0.2	1.4	4.3	9.9	43.4	1.2	3.4	34.2	3.4	4.0	85.6	991	578	98	151	34	10	60	59	+26
Trail Blazers	13.1	36	23.7	2.1	3.1	0.9	0.2	1.5	4.3	11.6	36.8	0.9	3.4	26.8	3.6	4.1	87.9	853	470	74	110	34	7	54	33	-7
Heat	13.0	44	23.3	1.9	3.3	0.6	0.1	1.7	4.1	10.6	38.7	1.5	3.9	37.0	3.4	4.0	84.2	1,026	573	84	145	28	3	75	54	+65
Pacers	12.9	43	23.8	2.0	2.9	0.7	0.2	1.7	4.3	10.6	41.1	1.2	3.6	33.8	3.0	3.6	83.7	1,023	554	88	125	28	10	75	66	-39
Mavericks	12.8	32	24.5	2.1	3.4	0.9	0.2	1.8	4.3	11.7	36.7	1.2	4.3	27.3	3.0	3.7	82.2	786	409	68	110	28	6	58	47	-54