Wilt Chamberlain has the most games with 45+ points in a season, with 53 games in 1961-62.

Interpreted as:

most 45 or more point games by a player in NBA season

	NAME	GP	PTS	SEASON	TM	MPG	PPG	RPG	APG	SPG	BPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TPG	MIN	REB	AST	STL	BLK	TOV	PF	+/-
1	Wilt Chamberlain W. Chamberlain	53	3,010	1961-62	PHI	48.8	56.8	26.3	2.2			22.6	42.8	52.8				11.6	18.3	63.4	55.8				2,584	1,395	118				91
2	Wilt Chamberlain W. Chamberlain	41	2,234	1962-63	SFW	48.7	54.5	25.0				22.4	41.0	54.6				9.7	15.9	61.1	56.8				1,995	1,024					67
3	Wilt Chamberlain W. Chamberlain	23	1,156	1960-61	PHI	48.3	50.3	27.1				20.5	36.2	56.5				9.3	16.8	55.4	57.6				1,110	624					37
4	Rick Barry R. Barry	18	873	1966-67	SFW	43.3	48.5	9.0	3.6			17.9	36.8	48.8				12.6	14.1	89.4	56.4				780	162	64				60
5	Michael Jordan M. Jordan	16	818	1986-87	CHI	41.5	51.1	5.7	4.1	3.6	1.7	17.8	32.2	55.3	0.1	1.1	11.8	15.4	17.4	88.2	64.1	1.9	3.8	3.5	664	91	66	57	27	56	47
6	Wilt Chamberlain W. Chamberlain	16	830	1963-64	SFW	48.3	51.9	21.1	5.1			20.9	39.6	52.7				10.1	17.2	58.9	55.0				773	338	82				41
7	Wilt Chamberlain W. Chamberlain	14	728	1964-65	TOT		52.0	24.5	2.4			21.6	41.4	52.3				8.7	17.4	50.2	53.1					343	34				23
8	Elgin Baylor E. Baylor	13	654	1960-61	LAL		50.3	22.7				18.8						12.8	16.5	77.6						295					56
9	James Harden J. Harden	12	646	2018-19	HOU	40.6	53.8	8.3	6.8	2.6	0.6	15.5	32.2	48.2	6.8	16.8	40.3	16.1	17.8	90.6	67.3	1.8	6.6	5.1	487	100	82	31	7	61	37	+126
10	Russell Westbrook R. Westbrook	12	586	2016-17	OKC	37.7	48.8	10.6	8.1	2.0	0.2	15.9	32.8	48.6	4.7	11.4	40.9	12.3	14.3	86.0	62.5	1.5	9.1	5.1	453	127	97	24	2	61	31	+54
11	Kobe Bryant K. Bryant	12	632	2006-07	LAL	46.2	52.7	6.3	4.0	1.3	0.4	18.0	33.5	53.7	3.6	7.4	48.3	13.1	14.9	87.7	65.7	0.9	5.4	2.5	555	76	48	16	5	30	36	+81
12	Michael Jordan M. Jordan	12	591	1987-88	CHI	41.5	49.3	5.3	5.9	2.9	1.9	18.4	29.8	61.9	0.1	1.1	7.7	12.3	14.2	87.1	68.4	1.8	3.5	2.8	498	64	71	35	23	34	44
13	Wilt Chamberlain W. Chamberlain	12	600	1959-60	PHI	47.5	50.0	31.0	2.1			20.8	40.0	52.1				8.3	13.9	59.9	54.2				570	372	25				27
14	Elgin Baylor E. Baylor	11	550	1961-62	LAL		50.0	20.7				18.1	39.5	45.7				13.8	17.7	77.9	52.8					228					38
15	James Harden J. Harden	10	515	2019-20	HOU	39.0	51.5	6.7	7.5	2.1	1.0	15.4	29.3	52.6	7.2	15.8	45.6	13.5	14.8	91.2	71.9	0.9	5.8	4.5	390	67	75	21	10	45	34	+131
16	Kobe Bryant K. Bryant	10	529	2005-06	LAL	42.7	52.9	7.2	3.2	2.1	0.2	17.6	34.8	50.6	4.9	10.4	47.1	12.8	15.2	84.2	63.8	1.2	6.0	3.3	427	72	32	21	2	33	31	+83
17	Michael Jordan M. Jordan	10	500	1989-90	CHI	42.9	50.0	8.7	5.2	3.0	0.9	19.5	31.9	61.1	0.9	2.4	37.5	10.1	11.4	88.6	67.7	2.1	6.6	2.2	429	87	52	30	9	22	33
18	Dominique Wilkins D. Wilkins	10	471	1987-88	ATL	41.9	47.1	8.0	3.5	1.9	0.6	17.5	31.4	55.7	1.2	2.2	54.5	10.9	12.7	85.8	63.7	3.9	4.1	3.9	419	80	35	19	6	39	21
19	Damian Lillard D. Lillard	9	474	2019-20	POR	40.5	52.7	5.4	9.1	1.3	0.0	16.2	29.0	55.9	8.2	15.2	54.0	12.0	12.7	94.7	76.2	0.3	5.1	2.7	364	49	82	12	0	24	10	+83
20	George Gervin G. Gervin	9	424	1981-82	SAS	39.7	47.1	5.9	3.1	1.2	0.3	18.7	30.0	62.2	0.1	0.6	20.0	9.7	10.9	88.8	67.7			3.6	357	53	28	11	3	32	23
21	Wilt Chamberlain W. Chamberlain	9	469	1965-66	PHI	47.1	52.1	26.3	2.8			21.0	35.7	58.9				10.1	16.2	62.3	60.9				424	237	25				15
22	Elgin Baylor E. Baylor	9	441	1962-63	LAL		49.0					18.2						12.6	14.6	86.3											32
23	Kobe Bryant K. Bryant	8	385	2002-03	LAL	42.8	48.1	5.1	3.9	1.6	0.9	17.0	32.8	51.9	4.4	7.6	57.4	9.8	11.4	85.7	63.7	0.1	5.0	3.1	342	41	31	13	7	25	22	+121
24	Allen Iverson A. Iverson	8	386	2000-01	PHI	47.3	48.3	3.9	4.1	2.6	0.4	17.3	33.8	51.1	2.5	5.6	44.4	11.3	13.0	86.5	61.1	0.9	3.0	4.9	378	31	33	21	3	39	26	+13
25	Bernard King B. King	8	380	1990-91	WAS	40.9	47.5	6.9	4.3	2.1	0.4	18.8	31.3	60.0	0.3	0.8	33.3	9.8	12.1	80.4	64.9	2.6	4.3	4.1	327	55	34	17	3	33	23