LeBron James has dropped the most career points in season openers, with 533 points.

most career points by a player in season openers

NAME	PTS	GP	MPG	PPG	RPG	APG	SPG	BPG	TPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	MIN	REB	AST	STL	BLK	TOV	PF	+/-
LeBron James	533	21	37.4	25.4	8.2	6.3	1.1	0.9	4.0	9.3	18.4	50.4	1.7	5.0	33.7	5.1	7.2	71.1	784	173	133	23	19	83	56	+40
Karl Malone	463	19	36.4	24.4	8.8	3.9	1.5	0.9	3.1	8.8	16.6	52.8	0.0	0.1	0.0	6.8	9.1	75.0	691	167	75	28	17	59	65	+14
Michael Jordan	431	14	38.2	30.8	5.9	4.5	3.2	1.4	2.6	11.3	23.2	48.6	0.4	1.9	18.5	7.9	10.0	78.6	535	82	63	45	19	37	41	-2
Kareem Abdul-Jabbar	430	19	37.1	22.6	11.1	2.9			3.1	9.2	18.1	50.6	0.0	0.0		4.3	6.5	66.7	704	210	55			37	61
Paul Pierce	417	17	36.9	24.5	8.0	3.9	1.2	0.5	2.4	8.0	16.3	49.1	1.8	4.4	41.9	6.7	9.2	73.1	628	136	66	20	9	41	47	+98
Dominique Wilkins	412	14	36.7	29.4	6.7	2.9	1.8	0.4	3.2	11.2	22.1	50.8	0.7	1.9	37.0	6.3	7.9	79.3	514	94	40	25	6	45	35	+9
Kobe Bryant	397	15	37.5	26.5	5.9	3.8	1.9	0.9	3.5	8.8	20.9	42.2	0.7	2.3	28.6	8.2	9.8	83.7	563	88	57	29	14	52	40	+55
Wilt Chamberlain	393	13	43.1	30.2	23.5	3.8				12.4	21.2	58.3				5.5	12.3	44.4	560	305	50				22
Dirk Nowitzki	388	19	33.7	20.4	8.2	2.6	0.8	0.9	1.7	7.1	15.4	45.7	1.5	3.8	39.7	4.8	5.6	85.8	641	156	50	15	17	33	53	+44
Elgin Baylor	384	14		27.4						10.2						7.0	9.4	74.2
Kevin Durant	380	15	35.7	25.3	7.3	3.4	1.3	1.1	3.0	8.7	20.1	43.4	1.4	4.7	30.0	6.5	7.9	81.5	535	110	51	20	17	45	37	+12
Moses Malone	378	18	33.6	21.0	11.8	1.2		1.7	2.6	7.1	13.6	52.5	0.0	0.0		6.8	8.8	76.7	604	212	22		30	44	41
Ray Allen	356	17	37.2	20.9	2.8	2.9	1.0	0.1	2.1	7.0	14.5	48.2	2.7	5.6	48.4	4.2	4.8	87.8	633	48	50	17	2	35	33	+64
Hakeem Olajuwon	352	18	35.2	19.6	11.2	2.2	1.9	2.6	3.2	7.6	14.8	51.3	0.0	0.0		4.3	7.3	59.5	634	202	39	35	47	58	76	-23
Adrian Dantley	352	13	35.9	27.1	7.2	1.8		0.3	2.9	8.6	16.8	51.4	0.0	0.2	0.0	9.8	12.5	78.5	467	94	23		4	35	44
Kevin Garnett	350	21	34.2	16.7	10.6	4.0	1.2	2.0	2.8	7.0	14.0	50.3	0.1	0.5	30.0	2.4	3.4	71.8	719	222	85	25	43	58	55	+104
Carmelo Anthony	340	17	32.2	20.0	5.8	2.6	1.0	0.5	2.6	7.1	16.8	42.1	1.2	3.6	34.4	4.6	6.1	76.7	548	99	45	17	9	45	55	+12
James Harden	339	14	33.5	24.2	5.5	8.4	1.3	0.5	3.3	6.9	15.5	44.2	2.6	7.4	35.9	7.9	8.6	90.9	469	77	117	18	7	46	34	-14
Charles Barkley	338	14	36.1	24.1	11.5	3.2	0.9	1.0	3.2	8.3	13.3	62.4	0.2	0.9	25.0	7.4	10.4	71.0	505	161	45	12	14	45	37	-22
Jerry West	337	12		28.1			5.0	0.0		10.4						7.3	9.3	78.4				5	0
Reggie Miller	334	16	35.1	20.9	3.6	2.8	1.0	0.4	3.0	5.9	13.2	45.0	1.4	4.7	29.3	7.6	8.3	92.4	561	58	44	16	7	48	55	0
Tim Duncan	332	19	31.9	17.5	10.9	2.5	0.7	2.2	2.7	6.8	12.6	54.4	0.0	0.1	0.0	3.8	5.4	69.9	607	207	48	14	42	52	50	+121
Alex English	329	15	31.7	21.9	6.3	2.7				9.4	17.9	52.6	0.0	0.0		3.1	4.1	75.8	476	95	40				35
Oscar Robertson	329	14		23.5	8.0	10.0	1.0	0.0		8.6	19.6	43.6				6.4	7.8	81.7		112	140	1	0		41
Vince Carter	328	21	29.6	15.6	3.9	2.7	0.8	0.4	1.5	5.5	13.0	42.6	0.8	3.5	23.0	3.8	4.7	80.6	623	81	57	17	9	32	63	+80