Between the 1999-00 and 2008-09 seasons, Kobe Bryant had the most points per game, with 28.2 per game.

Interpreted as:

most points per game with a minimum of 41 games played per 82 team games by a player in the 2000s

	NAME	PPG	GP	MPG	RPG	APG	SPG	BPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TPG	MIN	PTS	REB	AST	STL	BLK	TOV	PF	+/-
1	Kobe Bryant K. Bryant	28.2	748	39.4	5.9	5.2	1.7	0.6	9.8	21.5	45.7	1.4	4.1	34.2	7.2	8.5	84.4	55.9	1.3	4.6	3.1	29,476	21,065	4,381	3,921	1,246	431	2,326	2,092	+3470
2	Allen Iverson A. Iverson	28.1	682	41.8	3.6	6.2	2.2	0.2	9.7	22.9	42.4	1.1	3.6	31.1	7.5	9.5	79.3	51.8	0.7	2.9	3.6	28,534	19,154	2,471	4,227	1,521	106	2,450	1,198	+1187
3	LeBron James L. James	27.5	472	40.6	7.0	6.7	1.8	0.9	9.8	20.9	47.1	1.4	4.1	32.8	6.5	8.8	73.8	55.5	1.3	5.7	3.3	19,142	12,993	3,307	3,159	830	405	1,541	951	+1669
4	Dwyane Wade D. Wade	25.2	394	37.9	4.9	6.7	1.8	1.0	8.8	18.2	48.3	0.4	1.5	28.5	7.2	9.3	77.2	56.5	1.2	3.6	3.8	14,925	9,922	1,925	2,625	720	379	1,497	1,019	+1026
5	Tracy McGrady T. McGrady	24.4	671	37.5	6.3	5.2	1.4	0.9	8.9	20.3	43.5	1.5	4.4	34.0	5.2	6.9	75.0	52.2	1.5	4.8	2.5	25,177	16,380	4,230	3,489	938	617	1,684	1,305	+1523
6	Carmelo Anthony C. Anthony	24.2	445	36.2	6.1	3.1	1.1	0.4	8.7	18.9	46.0	0.7	2.3	30.7	6.1	7.7	79.6	54.3	2.0	4.2	3.1	16,113	10,768	2,730	1,367	503	199	1,375	1,334	+790
7	Vince Carter V. Carter	23.9	727	37.8	5.4	4.4	1.3	0.7	8.7	19.5	44.6	1.6	4.3	37.8	4.8	6.1	79.9	53.8	1.6	3.9	2.4	27,511	17,341	3,960	3,166	914	525	1,741	2,211	+731
8	Dirk Nowitzki D. Nowitzki	23.6	792	37.5	8.9	2.8	0.9	1.0	8.2	17.3	47.4	1.3	3.5	38.2	5.9	6.7	87.4	58.3	1.3	7.6	2.0	29,734	18,699	7,020	2,200	747	830	1,545	2,073	+4665
9	Paul Pierce P. Pierce	23.3	765	37.8	6.3	4.0	1.5	0.6	7.6	17.1	44.3	1.7	4.6	36.3	6.4	8.0	80.1	56.3	1.0	5.3	3.1	28,893	17,812	4,798	3,068	1,183	480	2,376	2,201	+1925
10	Shaquille O'Neal S. O'Neal	23.1	662	34.7	10.6	2.7	0.5	2.2	9.1	15.5	58.5	0.0	0.0	0.0	5.0	9.5	52.2	58.7	3.4	7.2	2.7	22,941	15,276	7,029	1,789	344	1,431	1,818	2,276	+3459
11	Gilbert Arenas G. Arenas	22.8	433	37.4	4.2	5.5	1.8	0.2	7.3	17.2	42.7	2.1	5.8	35.8	6.0	7.4	80.9	55.7	0.9	3.3	3.3	16,175	9,853	1,828	2,387	758	103	1,438	1,365	+96
12	Kevin Durant K. Durant	22.7	154	36.7	5.4	2.6	1.1	0.8	8.1	17.9	45.3	1.0	2.8	35.9	5.5	6.3	86.7	54.9	1.0	4.4	3.0	5,653	3,495	830	397	174	128	457	256	-1152
13	Ray Allen R. Allen	22.1	728	37.9	4.4	3.8	1.2	0.2	7.7	17.1	45.2	2.7	6.7	40.3	4.0	4.4	90.0	58.2	1.1	3.4	2.3	27,561	16,101	3,238	2,801	901	143	1,674	1,623	+2189
14	Karl Malone K. Malone	21.8	366	36.0	8.5	4.2	1.4	0.7	7.8	16.1	48.1	0.0	0.1	30.2	6.2	7.9	78.5	55.5	1.6	6.9	2.9	13,191	7,982	3,129	1,548	510	243	1,051	994	+1303
15	Kevin Garnett K. Garnett	21.6	769	38.2	12.1	4.7	1.3	1.6	8.5	17.1	49.9	0.2	0.7	28.6	4.4	5.6	79.4	55.4	2.6	9.4	2.6	29,345	16,638	9,288	3,603	1,037	1,206	2,003	1,882	+3322
16	Tim Duncan T. Duncan	21.4	767	36.5	11.7	3.3	0.8	2.3	8.2	16.2	50.4	0.0	0.1	20.7	5.1	7.4	68.6	55.1	3.1	8.7	2.7	27,974	16,431	8,999	2,502	589	1,786	2,070	1,993	+5468
17	Michael Jordan M. Jordan	21.2	142	36.1	5.9	4.4	1.5	0.5	8.7	20.1	43.1	0.2	0.8	24.1	3.7	4.6	80.5	48.0	0.9	5.0	2.4	5,124	3,015	836	621	208	65	335	290	+22
18	Chris Webber C. Webber	21.1	501	36.8	9.7	4.3	1.4	1.2	8.7	18.9	46.1	0.2	0.6	26.7	3.5	4.8	71.4	50.1	2.3	7.3	2.7	18,450	10,569	4,836	2,146	701	592	1,328	1,544	+1310
19	Amar'e Stoudemire A. Stoudemire	21.1	434	34.2	8.9	1.4	0.9	1.5	7.6	14.0	54.1	0.0	0.2	19.2	5.9	7.8	75.5	60.4	2.6	6.3	2.6	14,848	9,139	3,881	595	395	639	1,112	1,491	+1465
20	Antawn Jamison A. Jamison	20.6	751	37.7	8.1	1.8	1.1	0.4	7.9	17.3	45.6	1.1	3.1	34.8	3.7	5.0	74.0	52.7	2.6	5.5	1.8	28,297	15,434	6,101	1,362	799	286	1,328	1,845	-837
21	Michael Redd M. Redd	20.5	550	34.0	4.1	2.3	1.0	0.1	7.2	16.0	45.2	1.8	4.6	38.6	4.3	5.1	84.3	56.3	1.1	3.0	1.6	18,708	11,295	2,272	1,254	545	63	907	945	-303
22	Glenn Robinson G. Robinson	20.3	343	35.4	6.1	2.6	1.2	0.5	8.0	17.5	45.9	0.9	2.8	33.6	3.3	3.9	83.5	52.7	1.3	4.8	2.8	12,152	6,957	2,087	883	398	182	977	874	-49
23	Jamal Mashburn J. Mashburn	20.1	293	39.1	6.2	4.7	1.0	0.2	7.6	18.0	42.0	1.3	3.6	37.5	3.6	4.4	81.5	50.3	0.9	5.3	2.6	11,469	5,882	1,814	1,389	306	55	768	718	+726
24	Elton Brand E. Brand	20.0	643	38.0	10.1	2.6	0.9	2.1	7.7	15.2	50.3	0.0	0.0	15.4	4.7	6.4	73.6	55.5	3.9	6.3	2.5	24,420	12,852	6,520	1,674	592	1,334	1,617	1,993	-1177
25	Brandon Roy B. Roy	19.8	209	36.9	4.6	5.1	1.1	0.2	7.2	15.6	46.5	1.0	2.8	36.3	4.3	5.4	80.3	55.2	1.2	3.5	1.9	7,710	4,136	968	1,060	234	48	404	413	+342