Trey Murphy III has his most career points per game against the Knicks, with 18.8 per game.

trey murphy iii highest career ppg by opponent

OPP	PPG	GP	MPG	RPG	APG	SPG	BPG	TPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	MIN	PTS	REB	AST	STL	BLK	TOV	PF	+/-
Knicks	18.8	4	30.2	3.3	2.3	0.5	0.5	0.3	6.0	11.8	51.1	2.5	6.8	37.0	4.3	4.5	94.4	121	75	13	9	2	2	1	9	+29
Trail Blazers	17.9	10	27.6	4.5	1.4	1.0	0.6	0.5	5.6	11.1	50.5	3.5	7.9	44.3	3.2	3.3	97.0	276	179	45	14	10	6	5	11	+113
Hornets	16.0	6	24.7	4.5	1.5	1.5	0.0	0.7	5.5	11.2	49.3	3.5	7.3	47.7	1.5	1.8	81.8	148	96	27	9	9	0	4	11	+17
Raptors	15.8	5	23.8	4.0	0.4	0.6	0.6	0.6	5.2	10.4	50.0	3.8	7.8	48.7	1.6	2.0	80.0	119	79	20	2	3	3	3	8	+88
Warriors	15.3	7	30.7	4.0	2.7	1.0	0.7	0.4	5.3	11.0	48.1	3.4	7.9	43.6	1.3	1.3	100.0	215	107	28	19	7	5	3	11	+19
Cavaliers	15.2	5	28.6	2.4	1.6	0.6	0.4	1.2	5.8	11.4	50.9	2.6	6.0	43.3	1.0	1.2	83.3	143	76	12	8	3	2	6	10	-37
Pacers	14.5	4	26.9	5.8	2.5	1.8	0.3	0.3	4.5	8.5	52.9	3.3	7.0	46.4	2.3	3.0	75.0	108	58	23	10	7	1	1	3	+26
Kings	13.8	10	26.5	2.7	2.3	0.6	0.3	0.6	4.4	7.9	55.7	3.1	6.0	51.7	1.9	2.3	82.6	265	138	27	23	6	3	6	11	+71
Grizzlies	13.4	9	25.4	3.0	1.0	0.9	0.2	0.4	4.1	9.0	45.7	2.2	5.2	42.6	3.0	3.3	90.0	229	121	27	9	8	2	4	16	-40
Spurs	11.8	10	23.4	2.9	1.7	1.1	0.3	0.4	4.4	9.3	47.3	1.9	5.5	34.5	1.1	1.3	84.6	234	118	29	17	11	3	4	16	+55
Pistons	11.8	5	23.7	4.0	1.8	0.8	1.2	0.4	3.0	8.4	35.7	1.8	6.4	28.1	4.0	4.4	90.9	119	59	20	9	4	6	2	8	+15
Magic	11.7	6	27.5	4.3	1.3	0.8	0.2	0.8	3.5	7.2	48.8	1.5	4.2	36.0	3.2	3.7	86.4	165	70	26	8	5	1	5	5	-46
Wizards	11.2	6	21.1	3.0	1.5	1.2	1.0	0.3	3.5	7.2	48.8	2.2	4.8	44.8	2.0	2.2	92.3	127	67	18	9	7	6	2	4	+65
Lakers	10.9	10	24.2	2.8	0.8	0.7	0.2	0.5	3.7	8.1	45.7	1.9	5.1	37.3	1.6	1.7	94.1	242	109	28	8	7	2	5	14	-43
Clippers	10.9	10	20.9	2.9	1.1	0.5	0.5	0.3	3.7	8.1	45.7	2.5	5.6	44.6	1.0	1.3	76.9	209	109	29	11	5	5	3	7	+59
Thunder	10.9	9	28.0	4.6	1.1	0.7	0.7	0.9	3.7	9.0	40.7	2.0	5.9	34.0	1.6	2.1	73.7	252	98	41	10	6	6	8	12	-24
Hawks	10.8	5	23.9	3.0	1.2	0.2	0.0	1.0	3.8	8.6	44.2	2.4	6.0	40.0	0.8	0.8	100.0	120	54	15	6	1	0	5	7	+21
Celtics	10.3	4	28.2	5.0	1.0	1.3	0.5	0.8	4.0	9.0	44.4	1.8	5.3	33.3	0.5	0.5	100.0	113	41	20	4	5	2	3	6	-33
Mavericks	10.3	8	24.1	2.9	1.0	0.5	0.4	0.5	3.3	5.5	59.1	1.6	3.4	48.1	2.1	2.5	85.0	193	82	23	8	4	3	4	19	-25
Timberwolves	9.9	7	22.4	2.7	0.9	0.6	0.3	0.4	3.1	5.7	55.0	1.6	3.9	40.7	2.0	2.4	82.4	157	69	19	6	4	2	3	11	+1
Nuggets	9.8	6	29.6	3.3	1.8	1.8	0.0	0.2	3.5	9.0	38.9	1.7	5.3	31.3	1.2	1.2	100.0	178	59	20	11	11	0	1	9	-15
Rockets	9.6	11	25.3	3.4	0.7	0.7	0.5	0.5	3.3	9.0	36.4	1.6	6.4	25.7	1.5	1.9	76.2	278	106	37	8	8	5	5	16	+51
Bucks	9.2	5	22.0	3.8	1.8	0.6	0.0	0.6	2.6	6.2	41.9	1.4	3.8	36.8	2.6	2.8	92.9	110	46	19	9	3	0	3	2	-37
Suns	9.1	10	26.1	4.1	1.4	1.0	0.5	0.9	3.0	8.3	36.1	2.0	5.6	35.7	1.1	1.3	84.6	261	91	41	14	10	5	9	18	-46
Nets	9.0	5	21.0	4.8	1.2	0.6	0.2	0.6	3.0	6.6	45.5	1.4	4.0	35.0	1.6	1.8	88.9	105	45	24	6	3	1	3	7	+31