The Portland Trail Blazers had their highest point differential in a game against the Cavaliers on November 21, 1982, with a 50 point differential.

what is the trail blazers largest margin of victory in a game

Interpreted as:

What is the trail blazers largest margin of victory in a regular-season game?

TEAM	DIFF	DATE	TM		OPP	RESULT	MIN	PTS	REB	AST	STL	BLK	TOV	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	PF
Portland Trail Blazers	50	11/21/1982	POR	vs	CLE	W 129-79	240	129	51	27	16	5	11	51	93	54.8	0	1	0.0	27	33	81.8	20
Portland Trail Blazers	48	4/3/2021	POR	vs	OKC	W 133-85	240	133	56	25	13	3	9	51	104	49.0	20	46	43.5	11	14	78.6	18
Portland Trail Blazers	48	10/18/2017	POR	@	PHX	W 124-76	240	124	57	22	8	7	16	44	90	48.9	14	24	58.3	22	28	78.6	20
Portland Trail Blazers	48	12/14/1994	POR	vs	LAC	W 121-73	240	121	66	27	7	5	20	51	93	54.8	7	12	58.3	12	20	60.0	23
Portland Trail Blazers	47	3/18/1972	POR	vs	NYK	W 133-86	240	133	60	39				56	95	58.9				21	30	70.0	20
Portland Trail Blazers	46	1/9/1995	POR	vs	LAL	W 129-83	240	129	50	37	12	9	17	51	95	53.7	11	20	55.0	16	21	76.2	19
Portland Trail Blazers	45	11/17/1997	POR	vs	DAL	W 120-75	240	120	59	36	13	6	11	50	92	54.3	7	14	50.0	13	21	61.9	18
Portland Trail Blazers	45	12/22/1987	POR	vs	GSW	W 136-91	240	136	58	36	10	7	22	47	83	56.6	3	4	75.0	39	51	76.5	18
Portland Trail Blazers	45	10/13/1973	POR	vs	CAP	W 132-87	240	132	61	35	16	10		57	109	52.3				18	24	75.0	23
Portland Trail Blazers	44	2/26/2014	POR	vs	BKN	W 124-80	240	124	53	29	6	6	11	46	86	53.5	13	31	41.9	19	21	90.5	15
Portland Trail Blazers	44	2/1/2012	POR	vs	CHA	W 112-68	240	112	43	26	18	11	17	44	80	55.0	7	14	50.0	17	20	85.0	18
Portland Trail Blazers	44	4/16/1997	POR	vs	DEN	W 107-63	240	107	64	21	15	2	19	43	94	45.7	3	13	23.1	18	24	75.0	15
Portland Trail Blazers	44	1/4/1977	POR	vs	BOS	W 128-84	240	128	63	28	14	10		57	113	50.4				14	20	70.0	27
Portland Trail Blazers	42	11/19/2008	POR	vs	CHI	W 116-74	240	116	49	24	10	10	16	42	83	50.6	7	16	43.8	25	31	80.6	21
Portland Trail Blazers	42	4/22/1990	POR	vs	LAL	W 130-88	240	130	56	37	8	8	12	53	95	55.8	1	8	12.5	23	34	67.6	26
Portland Trail Blazers	42	11/19/1977	POR	vs	CLE	W 109-67	240	109	67	17	12	4	20	39	82	47.6				31	39	79.5	24
Portland Trail Blazers	42	11/5/1976	POR	vs	PHI	W 146-104	240	146	48	27	15	5		55	93	59.1				36	49	73.5	24
Portland Trail Blazers	41	3/17/2011	POR	vs	CLE	W 111-70	240	111	45	29	8	2	12	45	83	54.2	11	27	40.7	10	13	76.9	19
Portland Trail Blazers	40	2/21/2012	POR	vs	SAS	W 137-97	240	137	47	31	5	7	9	51	86	59.3	15	28	53.6	20	24	83.3	21
Portland Trail Blazers	40	3/7/1999	POR	vs	HOU	W 111-71	240	111	39	26	12	7	16	42	76	55.3	9	16	56.3	18	21	85.7	24
Portland Trail Blazers	40	11/23/1996	POR	vs	DEN	W 105-65	240	105	53	27	6	7	21	40	76	52.6	10	23	43.5	15	23	65.2	25
Portland Trail Blazers	40	2/2/1992	POR	vs	SAC	W 147-107	240	147	53	33	11	7	12	54	100	54.0	4	9	44.4	35	40	87.5	27
Portland Trail Blazers	40	11/22/1983	POR	vs	DEN	W 156-116	240	156	51	40	8	7	10	65	100	65.0	0	0		26	31	83.9	21
Portland Trail Blazers	40	11/11/1977	POR	@	ATL	W 132-92	240	132	51	29	11	3	25	51	84	60.7				30	36	83.3	24
Portland Trail Blazers	39	1/21/1992	POR	vs	LAL	W 131-92	240	131	38	37	9	2	13	49	83	59.0	6	9	66.7	27	35	77.1	23