James Harden has dropped the most points in a game with 16+ assists, with 53 points against the Knicks on December 31, 2016.

Interpreted as:

highest scoring regular-season game with 16+ assists by a player

	NAME	PTS	AST	DATE	TM		OPP	MIN	REB	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF	+/-
1	James Harden J. Harden	53	17	12/31/2016	HOU	vs	NYK	42	16	0	0	14	26	53.8	9	16	56.3	16	18	88.9	78.1	3	13	8	2	+13
2	Trae Young T. Young	49	16	3/1/2019	ATL	vs	CHI	56	8	1	1	17	33	51.5	6	13	46.2	9	11	81.8	64.7	1	7	9	2	-9
3	Isiah Thomas I. Thomas	47	17	12/13/1983	DET	@	DEN	52	5	4	1	18	34	52.9	1	2	50.0	10	19	52.6	55.5	2	3	2	5
4	James Harden J. Harden	44	17	12/26/2020	HOU	@	POR	43	4	1	0	12	21	57.1	6	13	46.2	14	16	87.5	78.5	1	3	5	1	-6
5	Oscar Robertson O. Robertson	44	22	3/5/1966	CIN	vs	NYK	53	8			16	22	72.7				12	12	100.0	80.6				4
6	Oscar Robertson O. Robertson	44	16	11/27/1965	CIN	@	NYK	48	5			14	19	73.7				16	16	100.0	84.5				2
7	Damian Lillard D. Lillard	43	16	2/17/2021	POR	@	NOP	38	4	1	1	14	28	50.0	7	16	43.8	8	8	100.0	68.2	1	3	4	1	+14
8	Oscar Robertson O. Robertson	43	20	2/19/1961	CIN	vs	LAL		9			15						13	15	86.7					5
9	Kevin Johnson K. Johnson	42	17	4/3/1994	PHX	vs	DEN	45	1	3	0	14	25	56.0	0	1	0.0	14	16	87.5	65.5	1	0	2	4
10	Pete Maravich P. Maravich	42	17	1/17/1975	NOJ	vs	SEA	43	10	4		16	34	47.1				10	12	83.3	53.5				4
11	Oscar Robertson O. Robertson	42	18	2/13/1962	CIN	vs	PHI	46	15			17	29	58.6				8	10	80.0	62.9				4
12	Russell Westbrook R. Westbrook	41	16	11/13/2016	OKC	vs	ORL	38	12	0	0	14	21	66.7	0	3	0.0	13	18	72.2	70.9	2	10	2	2	+9
13	Chris Paul C. Paul	41	17	4/1/2015	LAC	@	POR	39	5	4	0	13	21	61.9	5	9	55.6	10	10	100.0	80.7	1	4	1	2	+6
14	Tim Hardaway T. Hardaway	41	18	4/25/1993	GSW	vs	SEA	45	7	2	1	13	26	50.0	5	13	38.5	10	11	90.9	66.5	1	6	3	3
15	Nate Archibald N. Archibald	41	21	12/15/1972	KCO	vs	DET	53	3			15	27	55.6				11	12	91.7	63.5				2
16	Nate Archibald N. Archibald	41	16	1/16/1972	CIN		CLE	46	4			14	25	56.0				13	15	86.7	64.9				4
17	Nate Archibald N. Archibald	41	16	1/7/1972	CIN	@	DET		0			16	22	72.7				9	10	90.0	77.7
18	Jerry West J. West	41	16	11/29/1970	LAL	vs	SDR	43	2			16	27	59.3				9	10	90.0	65.3				2
19	Oscar Robertson O. Robertson	41	16	12/28/1967	CIN		SFW	48	8			14	24	58.3				13	14	92.9	68.0				1
20	Oscar Robertson O. Robertson	41	17	11/10/1965	CIN	vs	NYK	48	8			14	21	66.7				13	14	92.9	75.5				4
21	LeBron James L. James	40	16	2/26/2013	MIA	vs	SAC	48	8	2	1	14	23	60.9	1	2	50.0	11	12	91.7	70.7	3	5	2	1	+11
22	Isiah Thomas I. Thomas	40	17	1/2/1988	DET	vs	DEN	43	2	2	0	16	23	69.6	2	4	50.0	6	9	66.7	74.2	1	1	3	3
23	Jerry West J. West	40	16	11/10/1965	LAL	vs	DET	48	2			11	22	50.0				18	18	100.0	66.8				2
24	Oscar Robertson O. Robertson	40	17	12/25/1961	CIN	vs	LAL	48	12			13	25	52.0				14	16	87.5	62.4				3
25	Oscar Robertson O. Robertson	40	16	11/10/1961	CIN	vs	CHI	48	15			13	24	54.2				14	14	100.0	66.3				3