Between the 2000-01 and 2012-13 seasons, Kobe Bryant had the most games with 25+ points, with 617 games.

Interpreted as:

most 25+ point regular-season games by a player 2000-01 to 2012-13

	NAME	GP	PTS	MPG	PPG	RPG	APG	SPG	BPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TPG	MIN	REB	AST	STL	BLK	TOV	PF	+/-
1	Kobe Bryant K. Bryant	617	20,768	40.4	33.7	5.9	4.9	1.7	0.5	11.7	24.4	47.9	1.8	5.0	36.9	8.5	10.0	85.0	58.5	1.3	4.7	3.2	24,926	3,662	3,053	1,019	303	1,991	1,641	+2990
2	LeBron James L. James	492	15,875	41.1	32.3	7.6	6.9	1.8	0.9	11.5	22.2	52.0	1.7	4.6	36.9	7.5	9.9	75.9	60.8	1.3	6.2	3.4	20,236	3,717	3,389	895	439	1,676	960	+2882
3	Dirk Nowitzki D. Nowitzki	453	13,716	39.6	30.3	9.3	2.8	1.0	1.1	10.5	20.2	52.1	1.7	3.7	44.9	7.6	8.4	89.8	63.3	1.3	8.0	2.1	17,940	4,223	1,291	454	486	931	1,158	+3383
4	Allen Iverson A. Iverson	398	13,265	43.8	33.3	3.8	6.5	2.5	0.2	11.4	25.3	45.0	1.4	4.1	34.3	9.2	11.3	81.6	55.2	0.7	3.2	3.8	17,419	1,530	2,586	991	67	1,515	692	+1307
5	Carmelo Anthony C. Anthony	379	11,870	38.5	31.3	6.8	3.1	1.2	0.5	11.1	22.3	49.7	1.3	3.4	37.3	7.8	9.5	82.9	59.1	2.1	4.7	3.0	14,598	2,592	1,187	453	192	1,145	1,182	+1701
6	Paul Pierce P. Pierce	361	11,044	39.9	30.6	6.9	4.1	1.7	0.6	9.9	19.9	49.9	2.3	5.3	43.5	8.5	10.4	81.5	62.6	0.9	6.0	3.2	14,419	2,491	1,485	596	225	1,159	1,056	+1863
7	Dwyane Wade D. Wade	333	10,572	39.4	31.7	5.5	6.6	1.9	1.2	11.2	21.0	53.3	0.8	2.2	33.9	8.6	10.8	79.7	61.7	1.4	4.1	3.5	13,104	1,832	2,202	623	392	1,173	843	+2103
8	Tracy McGrady T. McGrady	323	10,559	40.7	32.7	7.0	5.5	1.7	0.8	11.8	25.1	47.0	2.2	5.7	38.7	6.9	9.0	77.2	56.3	1.6	5.4	2.7	13,130	2,255	1,772	535	269	866	631	+1651
9	Vince Carter V. Carter	311	9,632	40.2	31.0	6.0	4.5	1.3	0.8	11.1	22.6	49.1	2.5	5.6	44.7	6.2	7.6	82.0	59.6	1.8	4.2	2.4	12,494	1,867	1,394	411	240	749	947	+1461
10	Kevin Durant K. Durant	289	9,005	40.3	31.2	7.5	3.3	1.4	1.0	10.4	20.5	50.8	1.9	4.6	41.4	8.4	9.4	89.2	63.2	0.9	6.6	3.4	11,649	2,165	959	394	302	973	571	+1291
11	Antawn Jamison A. Jamison	263	7,724	41.2	29.4	9.4	1.9	1.1	0.4	10.9	21.2	51.7	1.8	4.2	44.3	5.6	7.3	76.7	60.2	3.1	6.4	1.8	10,830	2,474	496	300	110	485	691	+326
12	Ray Allen R. Allen	247	7,476	40.4	30.3	4.8	4.1	1.4	0.1	10.5	20.1	51.9	4.1	8.5	48.0	5.3	5.8	91.0	66.7	1.1	3.7	2.5	9,976	1,194	1,002	344	34	612	567	+1012
13	Tim Duncan T. Duncan	241	7,005	39.5	29.1	12.8	3.3	0.8	2.4	11.0	19.5	56.4	0.1	0.2	24.5	7.0	9.6	72.6	61.2	3.4	9.4	2.8	9,514	3,084	801	186	590	678	661	+1785
14	Shaquille O'Neal S. O'Neal	224	6,865	38.3	30.6	11.9	3.2	0.6	2.4	11.9	19.2	62.2	0.0	0.0	0.0	6.8	12.4	54.8	62.2	4.1	7.8	2.9	8,584	2,672	710	136	532	646	774	+1593
15	Amar'e Stoudemire A. Stoudemire	223	6,813	37.6	30.6	9.7	1.7	0.9	1.6	11.1	18.9	58.9	0.1	0.3	21.2	8.2	10.4	79.2	65.1	3.0	6.8	2.7	8,389	2,173	378	204	348	597	743	+1134
16	Kevin Garnett K. Garnett	214	6,086	40.1	28.4	13.3	4.8	1.3	1.7	10.9	19.4	55.9	0.3	0.7	39.1	6.4	7.8	82.6	62.2	2.9	10.4	2.6	8,582	2,846	1,029	284	361	549	561	+1287
17	Gilbert Arenas G. Arenas	208	6,728	41.7	32.3	4.5	5.8	2.0	0.2	10.4	21.8	47.9	3.1	7.6	41.5	8.4	10.2	82.0	61.6	0.9	3.6	3.5	8,681	935	1,208	408	48	731	722	+615
18	Joe Johnson J. Johnson	193	5,737	41.7	29.7	4.8	5.2	1.1	0.2	11.3	21.2	53.2	2.9	6.0	48.5	4.3	5.3	80.3	63.3	1.1	3.7	2.6	8,055	918	1,006	208	46	509	389	+913
19	Michael Redd M. Redd	190	5,699	39.6	30.0	4.6	2.8	1.1	0.1	10.2	20.8	49.1	2.5	5.9	42.8	7.0	8.2	86.0	61.5	1.1	3.4	1.9	7,517	867	525	202	27	363	376	+389
20	Chris Bosh C. Bosh	180	5,307	40.1	29.5	9.9	2.5	0.9	1.2	10.2	18.2	55.9	0.2	0.5	44.2	8.9	10.7	83.4	64.3	3.0	6.9	2.3	7,221	1,788	450	153	217	417	443	+779
21	Jason Richardson J. Richardson	167	4,938	40.0	29.6	6.5	3.2	1.5	0.6	11.0	20.9	52.7	3.5	7.1	49.0	4.1	5.5	74.5	63.5	1.6	5.0	2.1	6,684	1,090	529	258	97	355	431	+630
22	Stephon Marbury S. Marbury	161	5,000	42.1	31.1	3.6	7.7	1.4	0.1	11.0	21.3	51.7	2.1	5.1	41.7	6.9	8.3	82.6	62.2	0.9	2.7	3.1	6,771	582	1,246	226	18	494	397	+118
23	Peja Stojakovic P. Stojakovic	155	4,478	41.4	28.9	6.2	2.3	1.2	0.2	9.9	18.4	54.0	3.7	7.4	50.0	5.3	5.8	91.5	68.9	1.3	4.9	1.8	6,419	956	359	187	25	272	348	+1117
24	Elton Brand E. Brand	150	4,298	40.7	28.7	10.7	2.8	1.0	2.3	11.0	18.7	59.1	0.0	0.0	0.0	6.6	8.2	79.8	64.2	3.8	6.9	2.4	6,112	1,609	423	156	346	357	476	+634
25	Pau Gasol P. Gasol	148	4,184	39.2	28.3	10.3	3.3	0.5	1.9	10.7	17.2	62.4	0.0	0.2	20.0	6.8	8.6	79.0	67.5	3.2	7.0	2.6	5,800	1,518	490	77	279	382	356	+495