Jayson Tatum had the highest plus/minus in 2021-22, at +667.

Interpreted as:

NBA highest plus-minus by a player 2021-22

NAME	+/-	SEASON	TM	GP	MPG	PPG	RPG	APG	SPG	BPG	TPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	MIN	PTS	REB	AST	STL	BLK	TOV	PF
Jayson Tatum	+667	2021-22	BOS	76	35.9	26.9	8.0	4.4	1.0	0.6	2.9	9.3	20.6	45.3	3.0	8.6	35.3	5.3	6.2	85.3	2,731	2,046	609	334	75	49	217	174
Mikal Bridges	+576	2021-22	PHX	82	34.8	14.2	4.2	2.3	1.2	0.4	0.8	5.6	10.5	53.4	1.4	3.8	36.9	1.6	1.9	83.4	2,854	1,162	347	185	96	36	68	150
Stephen Curry	+507	2021-22	GSW	64	34.5	25.5	5.2	6.3	1.3	0.4	3.2	8.4	19.1	43.7	4.5	11.7	38.0	4.3	4.7	92.3	2,211	1,630	335	404	85	23	206	130
Devin Booker	+469	2021-22	PHX	68	34.5	26.8	5.0	4.8	1.1	0.4	2.4	9.7	20.9	46.6	2.7	7.0	38.3	4.6	5.3	86.8	2,345	1,822	342	329	77	26	162	180
Chris Paul	+460	2021-22	PHX	65	32.9	14.7	4.4	10.8	1.9	0.3	2.4	5.6	11.3	49.3	1.0	3.1	31.7	2.6	3.1	83.7	2,139	958	283	702	121	20	153	134
Jaylen Brown	+453	2021-22	BOS	66	33.6	23.6	6.1	3.5	1.1	0.3	2.7	8.7	18.4	47.3	2.5	7.0	35.8	3.7	4.8	75.8	2,220	1,559	404	231	70	18	178	163
Marcus Smart	+443	2021-22	BOS	71	32.3	12.1	3.8	5.9	1.7	0.3	2.2	4.2	10.1	41.8	1.7	5.1	33.1	2.0	2.5	79.3	2,296	861	270	417	119	18	159	160
Nikola Jokic	+442	2021-22	DEN	74	33.5	27.1	13.8	7.9	1.5	0.9	3.8	10.3	17.7	58.3	1.3	3.9	33.7	5.1	6.3	81.0	2,476	2,004	1,019	584	109	63	281	191
Jrue Holiday	+426	2021-22	MIL	67	32.9	18.3	4.5	6.8	1.6	0.4	2.7	7.1	14.2	50.1	2.0	4.8	41.1	2.0	2.7	76.1	2,207	1,225	301	457	108	29	183	133
Rudy Gobert	+417	2021-22	UTA	66	32.1	15.6	14.7	1.1	0.7	2.1	1.8	5.5	7.7	71.3	0.0	0.1	0.0	4.6	6.7	69.0	2,120	1,027	968	72	45	137	119	176
Giannis Antetokounmpo	+397	2021-22	MIL	67	32.9	29.9	11.6	5.8	1.1	1.4	3.3	10.3	18.6	55.3	1.1	3.6	29.3	8.3	11.4	72.2	2,204	2,002	778	388	72	91	219	212
Jae Crowder	+395	2021-22	PHX	67	28.1	9.4	5.3	1.9	1.4	0.4	0.8	3.2	8.1	39.9	1.9	5.4	34.8	1.1	1.3	78.9	1,886	632	354	124	95	30	55	173
Al Horford	+386	2021-22	BOS	69	29.1	10.2	7.7	3.4	0.7	1.3	0.9	3.9	8.2	46.7	1.3	3.8	33.6	1.2	1.4	84.2	2,005	701	530	232	49	92	65	130
Jordan Clarkson	+383	2021-22	UTA	79	27.1	16.0	3.5	2.5	0.8	0.2	1.6	5.9	14.1	41.9	2.4	7.6	31.8	1.8	2.2	82.8	2,141	1,266	273	194	66	16	129	149
Darius Garland	+376	2021-22	CLE	68	35.7	21.7	3.3	8.6	1.3	0.1	3.6	8.0	17.3	46.2	2.6	6.7	38.3	3.2	3.5	89.2	2,430	1,473	224	583	89	7	248	115
Robert Williams III	+370	2021-22	BOS	61	29.6	10.0	9.6	2.0	0.9	2.2	1.0	4.4	6.0	73.6	0.0	0.0	0.0	1.1	1.5	72.2	1,804	607	588	121	56	134	63	137
Joel Embiid	+367	2021-22	PHI	68	33.8	30.6	11.7	4.2	1.1	1.5	3.1	9.8	19.6	49.9	1.4	3.7	37.1	9.6	11.8	81.4	2,297	2,079	796	284	77	99	214	181
Jaren Jackson Jr.	+361	2021-22	MEM	78	27.3	16.3	5.8	1.1	0.9	2.3	1.7	5.5	13.3	41.5	1.6	5.1	31.9	3.6	4.4	82.3	2,126	1,272	454	86	73	177	130	272
Desmond Bane	+361	2021-22	MEM	76	29.8	18.2	4.4	2.7	1.2	0.4	1.5	6.7	14.5	46.1	3.0	6.9	43.6	1.8	2.0	90.3	2,266	1,384	334	208	92	29	111	196
Steven Adams	+353	2021-22	MEM	76	26.3	6.9	10.0	3.4	0.9	0.8	1.5	2.8	5.1	54.7	0.0	0.0	0.0	1.4	2.6	54.3	1,999	528	760	256	65	60	115	153
Mike Conley	+348	2021-22	UTA	72	28.6	13.7	3.0	5.3	1.3	0.3	1.7	4.8	11.0	43.5	2.3	5.8	40.8	1.8	2.3	79.6	2,058	986	217	385	96	21	123	142
Deandre Ayton	+344	2021-22	PHX	58	29.5	17.2	10.2	1.4	0.7	0.7	1.6	7.6	12.0	63.4	0.1	0.3	36.8	1.8	2.4	74.6	1,713	997	593	84	40	40	91	142
Jordan Poole	+324	2021-22	GSW	76	30.0	18.5	3.4	4.0	0.8	0.3	2.5	6.2	13.9	44.8	2.8	7.6	36.4	3.2	3.5	92.5	2,283	1,405	260	304	60	23	187	206
Aaron Gordon	+321	2021-22	DEN	75	31.7	15.0	5.9	2.5	0.6	0.6	1.8	5.8	11.1	52.0	1.2	3.5	33.5	2.3	3.1	74.3	2,376	1,126	439	188	44	44	133	148
Bobby Portis	+314	2021-22	MIL	72	28.2	14.6	9.1	1.2	0.7	0.7	1.3	5.8	12.1	47.9	1.8	4.7	39.3	1.2	1.6	75.2	2,028	1,052	657	86	53	51	90	174