Between the 2000 and 2026 seasons, running backs have their most rushing yards in a game in a 34 to 31 win by the Dolphins over the Bills on December 24, 2016, with 474 yards.
Interpreted as:
2000 to 2026 NFL running back rushing yard in a regular-season game leaders| POSITION | RUSH YDS | DATE | TM | OPP | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Running Back | 474 | 12/24/2016 | vs | 73 | 6.5 | 3 | 85 | 10 | 12 | 8.5 | 0 | ||
| 2 | Running Back | 463 | 11/1/2009 | vs | 49 | 9.4 | 4 | 8 | 4 | 8 | 2.0 | 0 | ||
| 3 | Running Back | 462 | 12/20/2009 | vs | 69 | 6.7 | 4 | 36 | 5 | 8 | 7.2 | 0 | ||
| 4 | Running Back | 461 | 12/28/2008 | vs | 64 | 7.2 | 5 | 85 | 7 | 12 | 12.1 | 0 | ||
| 5 | Running Back | 441 | 9/30/2007 | @ | 67 | 6.6 | 1 | 43 | 7 | 8 | 6.1 | 0 | ||
| 6 | Running Back | 439 | 12/21/2008 | @ | 73 | 6.0 | 7 | 41 | 5 | 9 | 8.2 | 0 | ||
| 7 | Running Back | 435 | 12/29/2013 | vs | 72 | 6.0 | 3 | 123 | 11 | 17 | 11.2 | 1 | ||
| 8 | Running Back | 425 | 10/18/2009 | vs | 73 | 5.8 | 1 | 92 | 9 | 16 | 10.2 | 0 | ||
| 9 | Running Back | 423 | 10/22/2000 | @ | 58 | 7.3 | 4 | 7 | 3 | 7 | 2.3 | 1 | ||
| 10 | Running Back | 421 | 12/1/2002 | @ | 67 | 6.3 | 3 | 69 | 9 | 18 | 7.7 | 0 | ||
| 11 | Running Back | 417 | 9/24/2023 | @ | 61 | 6.8 | 5 | 128 | 15 | 17 | 8.5 | 3 | ||
| 12 | Running Back | 414 | 10/30/2005 | @ | 58 | 7.1 | 1 | 23 | 8 | 10 | 2.9 | 1 | ||
| 13 | Running Back | 412 | 1/3/2021 | @ | 52 | 7.9 | 2 | 13 | 2 | 3 | 6.5 | 0 | ||
| 14 | Running Back | 412 | 9/30/2007 | vs | 62 | 6.6 | 1 | 85 | 8 | 12 | 10.6 | 0 | ||
| 15 | Running Back | 410 | 10/7/2018 | @ | 52 | 7.9 | 1 | 107 | 12 | 15 | 8.9 | 0 | ||
| 16 | Running Back | 406 | 10/9/2022 | @ | 57 | 7.1 | 5 | 69 | 9 | 10 | 7.7 | 1 | ||
| 17 | Running Back | 405 | 11/22/2015 | @ | 64 | 6.3 | 0 | 91 | 10 | 18 | 9.1 | 2 | ||
| 18 | Running Back | 404 | 12/10/2006 | vs | 57 | 7.1 | 5 | 56 | 6 | 9 | 9.3 | 0 | ||
| 19 | Running Back | 403 | 1/2/2011 | vs | 64 | 6.3 | 4 | 51 | 7 | 10 | 7.3 | 0 | ||
| 20 | Running Back | 400 | 12/23/2012 | @ | 58 | 6.9 | 1 | 36 | 2 | 5 | 18.0 | 0 | ||
| 21 | Running Back | 399 | 12/23/2007 | vs | 70 | 5.7 | 4 | 48 | 3 | 6 | 16.0 | 0 | ||
| 22 | Running Back | 397 | 11/8/2020 | @ | 59 | 6.7 | 2 | 151 | 12 | 16 | 12.6 | 1 | ||
| 23 | Running Back | 397 | 11/4/2007 | @ | 57 | 7.0 | 5 | 79 | 9 | 15 | 8.8 | 0 | ||
| 24 | Running Back | 396 | 11/24/2013 | vs | 76 | 5.2 | 2 | 94 | 13 | 17 | 7.2 | 0 | ||
| 25 | Running Back | 396 | 10/14/2007 | vs | 65 | 6.1 | 3 | 55 | 8 | 15 | 6.9 | 0 | ||
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More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |