The San Francisco 49ers have a 74-72-2 record against the spread in the regular-season and playoffs at home since 2009.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/20/2009 | 1-0 | -120 | vs | +100 | W 23-10 | -1 | +12 (Y) | 39.5 | -6.5 (U) | 2 | 16 | 379 | 283 | 33.3 | |||
| 2 | | 49ers | 10/4/2009 | 1-0 | -475 | vs | +350 | W 35-0 | -9.5 | +25.5 (Y) | 37 | -2 (U) | 5 | 13 | 228 | 177 | 30.8 | |||
| 3 | | 49ers | 10/11/2009 | 0-1 | -115 | vs | -105 | L 10-45 | -2.5 | -37.5 (N) | 40 | +15 (O) | 1 | 13 | 279 | 477 | 28.6 | 50.0 | ||
| 4 | | 49ers | 11/8/2009 | 0-1 | -220 | vs | +180 | L 27-34 | -4.5 | -11.5 (N) | 40.5 | +20.5 (O) | 3 | 25 | 358 | 315 | 30.8 | 100.0 | ||
| 5 | | 49ers | 11/12/2009 | 1-0 | -175 | vs | +155 | W 10-6 | -3.5 | +0.5 (Y) | 42 | -26 (U) | 1 | 12 | 216 | 350 | 42.9 | 0.0 | ||
| 6 | | 49ers | 11/29/2009 | 1-0 | -175 | vs | +155 | W 20-3 | -3.5 | +13.5 (Y) | 41.5 | -18.5 (U) | 2 | 15 | 284 | 357 | 50.0 | 100.0 | ||
| 7 | | 49ers | 12/14/2009 | 1-0 | +185 | vs | -225 | W 24-9 | +3 | +18 (Y) | 44.5 | -11.5 (U) | 3 | 18 | 327 | 245 | 50.0 | |||
| 8 | | 49ers | 12/27/2009 | 0-0-1 | -900 | vs | +650 | W 20-6 | -14 | 0 (P) | 40.5 | -14.5 (U) | 2 | 13 | 310 | 289 | 29.4 | 50.0 | ||
| 9 | | 49ers | 9/20/2010 | 1-0 | +190 | vs | -230 | L 22-25 | +5.5 | +2.5 (Y) | 44 | +3 (O) | 3 | 24 | 417 | 287 | 55.6 | |||
| 10 | | 49ers | 10/10/2010 | 0-1 | -180 | vs | +160 | L 24-27 | -3 | -6 (N) | 38.5 | +12.5 (O) | 3 | 21 | 364 | 352 | 61.5 | |||
| 11 | | 49ers | 10/17/2010 | 1-0 | -355 | vs | +295 | W 17-9 | -7 | +1 (Y) | 41 | -15 (U) | 2 | 17 | 349 | 179 | 41.2 | |||
| 12 | | 49ers | 10/31/2010 | 1-0 | -135 | vs | +115 | W 24-16 | -2 | +6 (Y) | 41.5 | -1.5 (U) | 3 | 16 | 339 | 398 | 38.5 | |||
| 13 | | 49ers | 11/14/2010 | 0-1 | -210 | vs | +180 | W 23-20 | -5 | -2 (N) | 38.5 | +4.5 (O) | 2 | 19 | 421 | 332 | 0.0 | 100.0 | ||
| 14 | | 49ers | 11/21/2010 | 0-1 | -190 | vs | +170 | L 0-21 | -3.5 | -24.5 (N) | 42 | -21 (U) | 0 | 11 | 189 | 299 | 25.0 | 0.0 | ||
| 15 | | 49ers | 12/12/2010 | 1-0 | -220 | vs | +180 | W 40-21 | -5 | +14 (Y) | 41.5 | +19.5 (O) | 4 | 10 | 336 | 361 | 41.2 | |||
| 16 | | 49ers | 1/2/2011 | 1-0 | -250 | vs | +210 | W 38-7 | -6.5 | +24.5 (Y) | 39 | +6 (O) | 5 | 16 | 362 | 279 | 18.2 | |||
| 17 | | 49ers | 9/11/2011 | 1-0 | -250 | vs | +210 | W 33-17 | -6 | +10 (Y) | 37.5 | +12.5 (O) | 3 | 12 | 209 | 219 | 8.3 | |||
| 18 | | 49ers | 9/18/2011 | 0-0-1 | +150 | vs | -170 | L 24-27 | +3 | 0 (P) | 41 | +10 (O) | 3 | 14 | 206 | 472 | 50.0 | |||
| 19 | | 49ers | 10/9/2011 | 1-0 | -150 | vs | +130 | W 48-3 | -3 | +42 (Y) | 41.5 | +9.5 (O) | 6 | 28 | 418 | 272 | 28.6 | 100.0 | ||
| 20 | | 49ers | 10/30/2011 | 1-0 | -450 | vs | +350 | W 20-10 | -9.5 | +0.5 (Y) | 38.5 | -8.5 (U) | 2 | 19 | 348 | 290 | 40.0 | 0.0 | ||
| 21 | | 49ers | 11/13/2011 | 1-0 | -230 | vs | +190 | W 27-20 | -4 | +3 (Y) | 42.5 | +4.5 (O) | 2 | 16 | 305 | 395 | 27.3 | |||
| 22 | | 49ers | 11/20/2011 | 1-0 | -600 | vs | +450 | W 23-7 | -10 | +6 (Y) | 41 | -11 (U) | 2 | 25 | 431 | 229 | 38.1 | 100.0 | ||
| 23 | | 49ers | 12/4/2011 | 1-0 | -800 | vs | +600 | W 26-0 | -14 | +12 (Y) | 38 | -12 (U) | 2 | 18 | 389 | 157 | 28.6 | |||
| 24 | | 49ers | 12/19/2011 | 1-0 | -165 | vs | +145 | W 20-3 | -2.5 | +14.5 (Y) | 38 | -15 (U) | 2 | 17 | 287 | 389 | 30.8 | |||
| 25 | | 49ers | 1/14/2012 | 1-0 | +145 | vs | -165 | W 36-32 | +3.5 | +7.5 (Y) | 47 | +21 (O) | 4 | 17 | 407 | 472 | 26.7 | |||
| Average | 0.3 | 2.7 | 20.0 | 355.7 | 317.9 | 39.8 | 0.0 | |||||||||||||
| Total | 74-72-2 | 395 | 2,955 | 52,638 | 47,053 | 39.8 | 47.8 | |||||||||||||
STL
CHIStatMuse has team, game-level data for spread records going back to the 1979 season.
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More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |