The San Francisco 49ers have a record of 11-11 against the spread in the regular season against the AFC at home since 2017.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 12/17/2017 | 0-1 | -135 | vs | +125 | W 25-23 | -2.5 | -0.5 (N) | 44.5 | +3.5 (O) | 1 | 23 | 414 | 328 | 50.0 | |||
| 2 | | 49ers | 12/24/2017 | 1-0 | +190 | vs | -210 | W 44-33 | +4 | +15 (Y) | 43 | +34 (O) | 6 | 26 | 369 | 472 | 66.7 | |||
| 3 | | 49ers | 11/1/2018 | 1-0 | +115 | vs | -125 | W 34-3 | +2 | +33 (Y) | 44 | -7 (U) | 4 | 18 | 405 | 242 | 41.7 | |||
| 4 | | 49ers | 12/9/2018 | 1-0 | +142 | vs | -152 | W 20-14 | +3 | +9 (Y) | 45.5 | -11.5 (U) | 2 | 24 | 389 | 274 | 30.8 | 0.0 | ||
| 5 | | 49ers | 9/22/2019 | 0-1 | -301 | vs | +242 | W 24-20 | -6.5 | -2.5 (N) | 44 | 0 (P) | 3 | 26 | 436 | 239 | 54.5 | |||
| 6 | | 49ers | 10/7/2019 | 1-0 | -227 | vs | +187 | W 31-3 | -4.5 | +23.5 (Y) | 48 | -14 (U) | 4 | 22 | 446 | 180 | 37.5 | 100.0 | ||
| 7 | | 49ers | 10/11/2020 | 0-1 | -390 | vs | +314 | L 17-43 | -8.5 | -34.5 (N) | 50.5 | +9.5 (O) | 2 | 19 | 259 | 436 | 20.0 | 0.0 | ||
| 8 | | 49ers | 12/7/2020 | 0-1 | -124 | vs | +105 | L 24-34 | -1.5 | -11.5 (N) | 48 | +10 (O) | 3 | 24 | 402 | 449 | 54.5 | 0.0 | ||
| 9 | | 49ers | 10/24/2021 | 0-1 | -176 | vs | +147 | L 18-30 | -3.5 | -15.5 (N) | 41.5 | +6.5 (O) | 2 | 13 | 280 | 295 | 9.1 | |||
| 10 | | 49ers | 1/2/2022 | 1-0 | -740 | vs | +507 | W 23-7 | -13.5 | +2.5 (Y) | 44.5 | -14.5 (U) | 2 | 19 | 416 | 222 | 38.5 | 0.0 | ||
| 11 | | 49ers | 10/23/2022 | 0-1 | -103 | vs | -118 | L 23-44 | +1 | -20 (N) | 49 | +18 (O) | 2 | 25 | 444 | 529 | 57.1 | |||
| 12 | | 49ers | 11/13/2022 | 0-1 | -361 | vs | +284 | W 22-16 | -8 | -2 (N) | 45.5 | -7.5 (U) | 2 | 22 | 387 | 238 | 52.9 | 100.0 | ||
| 13 | | 49ers | 12/4/2022 | 1-0 | -233 | vs | +191 | W 33-17 | -5 | +11 (Y) | 46 | +4 (O) | 3 | 24 | 351 | 308 | 42.1 | 50.0 | ||
| 14 | | 49ers | 10/29/2023 | 0-1 | -211 | vs | +173 | L 17-31 | -4 | -18 (N) | 44 | +4 (O) | 2 | 24 | 460 | 400 | 55.6 | |||
| 15 | | 49ers | 12/25/2023 | 0-1 | -296 | vs | +238 | L 19-33 | -6.5 | -20.5 (N) | 47 | +5 (O) | 2 | 21 | 429 | 343 | 42.9 | 33.3 | ||
| 16 | | 49ers | 9/9/2024 | 1-0 | -195 | vs | +163 | W 32-19 | -3.5 | +9.5 (Y) | 43 | +8 (O) | 2 | 24 | 401 | 266 | 46.2 | |||
| 17 | | 49ers | 9/29/2024 | 1-0 | -585 | vs | +432 | W 30-13 | -10.5 | +6.5 (Y) | 42.5 | +0.5 (O) | 3 | 19 | 431 | 216 | 53.8 | |||
| 18 | | 49ers | 10/20/2024 | 0-1 | -143 | vs | +121 | L 18-28 | -2.5 | -12.5 (N) | 48 | -2 (U) | 2 | 19 | 310 | 329 | 18.2 | 100.0 | ||
| 19 | | 49ers | 9/28/2025 | 0-1 | -178 | vs | +144 | L 21-26 | -3.5 | -8.5 (N) | 45.5 | +1.5 (O) | 2 | 22 | 389 | 325 | 61.5 | 0.0 | ||
| 20 | | 49ers | 12/14/2025 | 1-0 | -952 | vs | +633 | W 37-24 | -12.5 | +0.5 (Y) | 44.5 | +16.5 (O) | 4 | 28 | 430 | 306 | 60.0 | 100.0 | ||
| 21 | | 49ers | 9/20/2026 | 1-0 | -980 | vs | +610 | W 35-13 | -13.5 | +8.5 (Y) | 45.5 | +2.5 (O) | 5 | 23 | 382 | 284 | 71.4 | |||
| 22 | | 49ers | 10/4/2026 | 1-0 | -175 | vs | +149 | W 24-14 | -3 | +7 (Y) | 48.5 | -10.5 (U) | 3 | 20 | 358 | 296 | 46.2 | 50.0 | ||
| Average | 2.3 | 2.8 | 22.0 | 390.4 | 317.1 | 46.1 | 0.0 | |||||||||||||
| Total | 11-11 | 61 | 485 | 8,588 | 6,977 | 46.1 | 38.9 |
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More 49ers Stats
Team Leaders 
PASS
1,196
Purdy
RUSH
286
McCaffrey
REC
326
Evans
Team Rankings
PPG
30.8
3rd
OPP PPG
18.6
3rd
RUSH YDS/G
128.6
8th
PASS YDS/G
239.2
15th
Seahawks
Rams
Cardinals
WAS
ATL
DAL
MIN
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 1 | .700 | |
2 | 3 | 0 | .400 | |
2 | 3 | 0 | .400 | |
1 | 3 | 1 | .300 | |
| NFC North | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
| NFC South | W | L | T | PCT |
2 | 2 | 0 | .500 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 | |
1 | 4 | 0 | .200 | |
| NFC West | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
2 | 2 | 0 | .500 | |
1 | 4 | 0 | .200 |
Giants
Eagles
Packers
Lions
Bears
Panthers
Buccaneers
Saints| AFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 0 | .750 | |
3 | 2 | 0 | .600 | |
2 | 3 | 0 | .400 | |
0 | 5 | 0 | .000 | |
| AFC North | W | L | T | PCT |
4 | 1 | 0 | .800 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
| AFC South | W | L | T | PCT |
4 | 1 | 0 | .800 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 | |
0 | 5 | 0 | .000 | |
| AFC West | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
0 | 5 | 0 | .000 |