The San Francisco 49ers had their highest point differential in a game against the Giants on September 27, 2020, with a 27-point differential.
Interpreted as:
49ers biggest margin of victory in a regular-season game vs giants| TEAM | DIFF | DATE | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 27 | 9/27/2020 | @ | W 36-9 | 4 | 29 | 420 | 231 | 66.7 | |||
| 2 | | 49ers | 24 | 11/30/1998 | vs | W 31-7 | 4 | 23 | 466 | 344 | 35.7 | |||
| 3 | | 49ers | 21 | 10/8/1984 | @ | W 31-10 | 4 | 18 | 384 | 389 | ||||
| 4 | | 49ers | 20 | 10/5/1987 | @ | W 41-21 | 5 | 27 | 433 | 231 | ||||
| 5 | | 49ers | 18 | 9/21/2023 | vs | W 30-12 | 3 | 26 | 441 | 150 | 56.3 | |||
| 6 | | 49ers | 17 | 9/6/1992 | @ | W 31-14 | 4 | 27 | 384 | 315 | 33.3 | 0.0 | ||
| 7 | | 49ers | 16 | 10/20/1968 | @ | W 26-10 | 3 | 22 | 393 | 272 | ||||
| 8 | | 49ers | 14 | 10/1/1995 | vs | W 20-6 | 2 | 22 | 311 | 237 | 53.3 | |||
| 9 | | 49ers | 12 | 11/23/1980 | vs | W 12-0 | 1 | 16 | 326 | 131 | ||||
| 10 | | 49ers | 10 | 11/2/2025 | @ | W 34-24 | 4 | 25 | 380 | 296 | 54.5 | 100.0 | ||
| 11 | | 49ers | 10 | 11/12/2017 | vs | W 31-21 | 4 | 21 | 474 | 374 | 66.7 | 0.0 | ||
| 12 | | 49ers | 10 | 11/27/1989 | vs | W 34-24 | 4 | 24 | 381 | 342 | ||||
| 13 | | 49ers | 10 | 12/1/1957 | @ | W 27-17 | 3 | 19 | 316 | 265 | ||||
| 14 | | 49ers | 7 | 11/13/2011 | vs | W 27-20 | 2 | 16 | 305 | 395 | 27.3 | |||
| 15 | | 49ers | 7 | 11/29/1981 | vs | W 17-10 | 2 | 19 | 337 | 223 | ||||
| 16 | | 49ers | 6 | 11/16/2014 | @ | W 16-10 | 1 | 20 | 333 | 330 | 42.9 | 0.0 | ||
| 17 | | 49ers | 4 | 12/3/1990 | vs | W 7-3 | 1 | 11 | 240 | 221 | ||||
| 18 | | 49ers | 3 | 9/5/2002 | @ | W 16-13 | 1 | 13 | 279 | 361 | 33.3 | |||
| 19 | | 49ers | 3 | 9/11/1988 | @ | W 20-17 | 2 | 25 | 430 | 309 | ||||
| 20 | | 49ers | -2 | 9/2/1991 | @ | L 14-16 | 2 | 14 | 258 | 331 | 33.3 | |||
| 21 | | 49ers | -2 | 9/25/1960 | vs | L 19-21 | 2 | 20 | 335 | 278 | ||||
| 22 | | 49ers | -3 | 10/11/2015 | @ | L 27-30 | 3 | 22 | 380 | 525 | 57.1 | |||
| 23 | | 49ers | -3 | 10/16/1977 | @ | L 17-20 | 2 | 16 | 275 | 154 | ||||
| 24 | | 49ers | -3 | 12/21/1975 | vs | L 23-26 | 3 | 20 | 350 | 328 | ||||
| 25 | | 49ers | -4 | 11/12/2018 | vs | L 23-27 | 2 | 24 | 374 | 277 | 61.5 | |||
More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
