The San Francisco 49ers had their most points in a game against the Bills on October 7, 2012, with 45 points.
Interpreted as:
49ers most points in a regular-season game against bills| TEAM | PTS | DATE | TM | OPP | RESULT | PASS TD | RUSH TD | RET TD | TD | FGM | XPM | XP2 | SFTY | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 45 | 10/7/2012 | vs | W 45-3 | 3 | 3 | 0 | 6 | 1 | 6 | 0 | 0 | ||
| 2 | | 49ers | 35 | 12/2/2001 | vs | W 35-0 | 2 | 3 | 0 | 5 | 0 | 5 | 0 | 0 | ||
| 3 | | 49ers | 31 | 9/13/1992 | vs | L 31-34 | 3 | 1 | 0 | 4 | 1 | 4 | 0 | |||
| 4 | | 49ers | 27 | 12/3/1995 | vs | W 27-17 | 0 | 2 | 1 | 3 | 2 | 3 | 0 | 0 | ||
| 5 | | 49ers | 24 | 12/7/2020 | vs | L 24-34 | 3 | 0 | 0 | 3 | 1 | 3 | 0 | 0 | ||
| 6 | | 49ers | 23 | 12/11/1983 | @ | W 23-10 | 1 | 1 | 0 | 2 | 3 | 2 | 0 | |||
| 7 | | 49ers | 21 | 10/4/1998 | @ | L 21-26 | 3 | 0 | 0 | 3 | 0 | 1 | 1 | 0 | ||
| 8 | | 49ers | 21 | 12/17/1989 | vs | W 21-10 | 1 | 2 | 0 | 3 | 0 | 3 | 0 | |||
| 9 | | 49ers | 20 | 9/24/1972 | @ | L 20-27 | 1 | 1 | 0 | 2 | 2 | 2 | 0 | |||
| 10 | | 49ers | 16 | 10/16/2016 | @ | L 16-45 | 1 | 0 | 0 | 1 | 3 | 1 | 0 | 0 | ||
| 11 | | 49ers | 13 | 12/21/1980 | vs | L 13-18 | 1 | 1 | 0 | 2 | 0 | 1 | 0 | |||
| 12 | | 49ers | 10 | 12/1/2024 | @ | L 10-35 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | ||
| 13 | | 49ers | 10 | 11/30/2008 | @ | W 10-3 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | ||
| 14 | | 49ers | 7 | 12/26/2004 | vs | L 7-41 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 |
More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
