Since 2000, the San Francisco 49ers have gained their most scrimmage yards in a game against the Bills on October 7, 2012, with 621 yards.
Interpreted as:
49ers most scrimmage yards in a regular-season game since 2000| TEAM | YDS | DATE | TM | OPP | RUSH YDS | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 621 | 10/7/2012 | vs | 311 | 38 | 8.2 | 3 | 310 | 19 | 25 | 16.3 | 3 | ||
| 2 | | 49ers | 571 | 9/15/2019 | @ | 259 | 42 | 6.2 | 2 | 312 | 18 | 26 | 17.3 | 3 | ||
| 3 | | 49ers | 546 | 12/8/2019 | @ | 162 | 24 | 6.8 | 1 | 384 | 27 | 35 | 14.2 | 5 | ||
| 4 | | 49ers | 541 | 12/10/2023 | vs | 173 | 23 | 7.5 | 2 | 368 | 19 | 27 | 19.4 | 2 | ||
| 5 | | 49ers | 519 | 10/14/2001 | @ | 187 | 35 | 5.3 | 2 | 332 | 27 | 40 | 12.3 | 3 | ||
| 6 | | 49ers | 515 | 12/14/2003 | @ | 171 | 27 | 6.3 | 3 | 344 | 26 | 32 | 13.2 | 2 | ||
| 7 | | 49ers | 503 | 12/28/2025 | vs | 200 | 34 | 5.9 | 3 | 303 | 24 | 33 | 12.6 | 3 | ||
| 8 | | 49ers | 502 | 9/8/2013 | vs | 90 | 34 | 2.6 | 1 | 412 | 27 | 39 | 15.3 | 3 | ||
| 9 | | 49ers | 499 | 12/7/2003 | vs | 232 | 36 | 6.4 | 3 | 267 | 20 | 29 | 13.4 | 4 | ||
| 10 | | 49ers | 496 | 10/7/2018 | vs | 147 | 34 | 4.3 | 1 | 349 | 34 | 54 | 10.3 | 2 | ||
| 11 | | 49ers | 491 | 11/6/2016 | vs | 93 | 17 | 5.5 | 0 | 398 | 24 | 39 | 16.6 | 2 | ||
| 12 | | 49ers | 489 | 11/27/2016 | @ | 193 | 25 | 7.7 | 0 | 296 | 29 | 45 | 10.2 | 3 | ||
| 13 | | 49ers | 487 | 12/30/2024 | vs | 75 | 18 | 4.2 | 2 | 412 | 30 | 36 | 13.7 | 3 | ||
| 14 | | 49ers | 483 | 10/27/2024 | vs | 223 | 36 | 6.2 | 2 | 260 | 18 | 25 | 14.4 | 1 | ||
| 15 | | 49ers | 483 | 10/10/2024 | @ | 228 | 33 | 6.9 | 1 | 255 | 18 | 27 | 14.2 | 3 | ||
| 16 | | 49ers | 480 | 12/2/2018 | @ | 66 | 23 | 2.9 | 0 | 414 | 30 | 42 | 13.8 | 2 | ||
| 17 | | 49ers | 479 | 12/17/2000 | vs | 77 | 28 | 2.8 | 0 | 402 | 36 | 43 | 11.2 | 2 | ||
| 18 | | 49ers | 478 | 10/29/2023 | vs | 113 | 23 | 4.9 | 1 | 365 | 22 | 30 | 16.6 | 1 | ||
| 19 | | 49ers | 475 | 1/9/2022 | @ | 135 | 31 | 4.4 | 1 | 340 | 24 | 32 | 14.2 | 2 | ||
| 20 | | 49ers | 474 | 10/25/2020 | @ | 197 | 37 | 5.3 | 4 | 277 | 20 | 25 | 13.9 | 0 | ||
| 21 | | 49ers | 474 | 11/12/2017 | vs | 186 | 33 | 5.6 | 2 | 288 | 19 | 25 | 15.2 | 2 | ||
| 22 | | 49ers | 474 | 10/10/2004 | vs | 57 | 19 | 3.0 | 0 | 417 | 38 | 57 | 11.0 | 2 | ||
| 23 | | 49ers | 473 | 11/17/2002 | @ | 136 | 31 | 4.4 | 0 | 337 | 25 | 42 | 13.5 | 2 | ||
| 24 | | 49ers | 472 | 10/8/2000 | vs | 136 | 34 | 4.0 | 0 | 336 | 28 | 40 | 12.0 | 4 | ||
| 25 | | 49ers | 470 | 10/23/2022 | vs | 101 | 21 | 4.8 | 0 | 369 | 29 | 46 | 12.7 | 2 | ||
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More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |