The San Francisco 49ers had their most all-purpose yards in a game with 1+ play versus the Bills on October 7, 2012, with 621 yards.
Interpreted as:
49ers most yards in a regular-season game gained on one or more play| TEAM | YDS | PLY | DATE | TM | OPP | RESULT | TD | PASS YDS | SCKY | PASS TD | RUSH YDS | RUSH TD | RET YDS | RET TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 621 | 63 | 10/7/2012 | vs | W 45-3 | 6 | 310 | 0 | 3 | 311 | 3 | 64 | 0 | ||
| 2 | | 49ers | 598 | 68 | 9/13/1992 | vs | L 31-34 | 4 | 449 | 10 | 3 | 159 | 1 | 75 | 0 | ||
| 3 | | 49ers | 597 | 80 | 12/13/1953 | vs | W 45-14 | 6 | 371 | 26 | 4 | 252 | 2 | 0 | |||
| 4 | | 49ers | 590 | 65 | 10/18/1992 | vs | W 56-17 | 8 | 399 | 0 | 3 | 191 | 5 | 38 | 0 | ||
| 5 | | 49ers | 580 | 85 | 9/25/1988 | @ | W 38-7 | 5 | 351 | 10 | 5 | 239 | 0 | 48 | 0 | ||
| 6 | | 49ers | 571 | 68 | 9/15/2019 | @ | W 41-17 | 5 | 312 | 0 | 3 | 259 | 2 | 17 | 0 | ||
| 7 | | 49ers | 565 | 65 | 12/19/1993 | @ | W 55-17 | 7 | 393 | 0 | 4 | 172 | 3 | 34 | 0 | ||
| 8 | | 49ers | 557 | 72 | 9/6/1998 | vs | W 36-30 | 5 | 363 | 13 | 3 | 207 | 2 | 129 | 0 | ||
| 9 | | 49ers | 555 | 68 | 10/15/1961 | @ | W 38-24 | 5 | 243 | 12 | 0 | 324 | 5 | 115 | 0 | ||
| 10 | | 49ers | 542 | 72 | 12/5/1999 | @ | L 30-44 | 4 | 437 | 0 | 3 | 105 | 1 | 86 | 0 | ||
| 11 | | 49ers | 539 | 66 | 11/28/1993 | @ | W 35-10 | 5 | 488 | 13 | 4 | 64 | 1 | 92 | 0 | ||
| 12 | | 49ers | 539 | 77 | 11/23/1958 | @ | W 33-12 | 4 | 283 | 0 | 3 | 256 | 1 | 0 | |||
| 13 | | 49ers | 538 | 73 | 9/27/1998 | vs | W 31-20 | 4 | 387 | 10 | 3 | 161 | 1 | 76 | 0 | ||
| 14 | | 49ers | 536 | 53 | 11/19/1961 | vs | W 41-31 | 5 | 322 | 4 | 3 | 218 | 2 | 92 | 0 | ||
| 15 | | 49ers | 534 | 82 | 9/10/1984 | vs | W 37-31 | 4 | 381 | 14 | 2 | 167 | 2 | 74 | 0 | ||
| 16 | | 49ers | 527 | 53 | 12/10/2023 | vs | W 28-16 | 4 | 368 | 14 | 2 | 173 | 2 | 69 | 0 | ||
| 17 | | 49ers | 527 | 64 | 9/18/1983 | @ | W 42-27 | 6 | 341 | 5 | 3 | 191 | 1 | 96 | 2 | ||
| 18 | | 49ers | 521 | 76 | 12/8/1984 | vs | W 51-7 | 6 | 346 | 9 | 3 | 184 | 3 | 88 | 0 | ||
| 19 | | 49ers | 521 | 67 | 10/8/1961 | vs | W 35-0 | 5 | 272 | 10 | 1 | 259 | 4 | 10 | 0 | ||
| 20 | | 49ers | 517 | 77 | 10/14/2001 | @ | W 37-31 | 5 | 332 | 2 | 3 | 187 | 2 | 153 | 0 | ||
| 21 | | 49ers | 517 | 74 | 10/21/1984 | @ | W 34-21 | 4 | 353 | 0 | 3 | 164 | 1 | 85 | 0 | ||
| 22 | | 49ers | 517 | 72 | 9/24/1967 | vs | W 38-7 | 5 | 353 | 16 | 2 | 180 | 3 | 95 | 0 | ||
| 23 | | 49ers | 516 | 63 | 12/8/2019 | @ | W 48-46 | 6 | 384 | 30 | 5 | 162 | 1 | 24 | 0 | ||
| 24 | | 49ers | 515 | 69 | 11/12/1989 | vs | W 45-3 | 6 | 286 | 6 | 3 | 235 | 2 | 127 | 1 | ||
| 25 | | 49ers | 510 | 61 | 10/3/1971 | @ | W 31-3 | 4 | 308 | 0 | 3 | 202 | 1 | 85 | 0 | ||
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More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |