Frank Gore has rushed for the most yards for the 49ers in a game, with 212 yards versus the Seahawks on November 19, 2006.
Interpreted as:
49ers player with most rushing yards in a regular-season game| NAME | RUSH YDS | DATE | TM | OPP | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | F. Gore | 212 | 11/19/2006 | vs | 24 | 8.8 | 0 | 26 | 4 | 4 | 6.5 | 0 | ||
| 2 | | F. Gore | 207 | 9/20/2009 | vs | 16 | 12.9 | 2 | 39 | 5 | 5 | 7.8 | 0 | ||
| 3 |  | C. Garner | 201 | 9/24/2000 | @ | 36 | 5.6 | 1 | 34 | 3 | 4 | 11.3 | 0 | ||
| 4 | | G. Hearst | 198 | 12/14/1998 | vs | 24 | 8.3 | 1 | 0 | 0 | 0 | ||||
| 5 | | D. Williams | 194 | 10/31/1976 | @ | 34 | 5.7 | 3 | 8 | 1 | 8.0 | 0 | |||
| 6 |  | C. Hyde | 193 | 12/11/2016 | vs | 17 | 11.4 | 0 | 7 | 1 | 1 | 7.0 | 1 | ||
| 7 | | R. Craig | 190 | 10/16/1988 | @ | 22 | 8.6 | 3 | 12 | 5 | 2.4 | 0 | |||
| 8 | | W. Jackson | 190 | 11/27/1977 | vs | 16 | 11.9 | 2 | 5 | 1 | 5.0 | 0 | |||
| 9 | | G. Hearst | 187 | 9/6/1998 | vs | 20 | 9.4 | 2 | 38 | 2 | 19.0 | 0 | |||
| 10 |  | J. Wilson Jr. | 183 | 12/26/2020 | @ | 22 | 8.3 | 0 | 21 | 1 | 2 | 21.0 | 1 | ||
| 11 | | D. Williams | 180 | 11/7/1976 | vs | 23 | 7.8 | 2 | 99 | 4 | 24.8 | 1 | |||
| 12 | | J. Perry | 174 | 11/2/1958 | vs | 13 | 13.4 | 1 | 22 | 2 | 11.0 | 0 | |||
| 13 | | H. McElhenny | 170 | 10/5/1952 | @ | 7 | 24.3 | 1 | 33 | 1 | 33.0 | 1 | |||
| 14 | | C. Hyde | 168 | 9/14/2015 | vs | 26 | 6.5 | 2 | 14 | 2 | 2 | 7.0 | 0 | ||
| 15 | | J.D. Smith | 168 | 11/26/1961 | vs | 28 | 6.0 | 2 | 0 | 0 | 0 | ||||
| 16 | | F. Gore | 167 | 12/14/2009 | vs | 25 | 6.7 | 1 | 10 | 2 | 3 | 5.0 | 0 | ||
| 17 | | C. Garner | 166 | 11/7/1999 | vs | 20 | 8.3 | 0 | 33 | 3 | 7 | 11.0 | 0 | ||
| 18 | | G. Hearst | 166 | 11/30/1998 | vs | 20 | 8.3 | 1 | 7 | 2 | 3.5 | 0 | |||
| 19 | | R. Watters | 163 | 11/22/1992 | @ | 26 | 6.3 | 2 | 16 | 3 | 5.3 | 0 | |||
| 20 | | R. Craig | 162 | 11/6/1988 | @ | 26 | 6.2 | 1 | 0 | 1 | 0.0 | 0 | |||
| 21 | | K. Willard | 162 | 12/15/1968 | @ | 25 | 6.5 | 2 | 16 | 2 | 8.0 | 0 | |||
| 22 | | F. Gore | 159 | 11/12/2006 | @ | 22 | 7.2 | 1 | 14 | 2 | 3 | 7.0 | 0 | ||
| 23 | | H. McElhenny | 159 | 11/23/1958 | @ | 22 | 7.2 | 1 | 19 | 2 | 9.5 | 0 | |||
| 24 | | F. Gore | 158 | 12/20/2014 | vs | 26 | 6.1 | 1 | 0 | 0 | 0 | 0 | |||
| 25 | | W. Jackson | 156 | 11/29/1976 | vs | 30 | 5.2 | 1 | 0 | 0 | 0 | ||||
STL
NYJ
RAM
WAS
DAL
PHXResults may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.
More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
