Frank Gore has the most rushing yards for the 49ers in a game, with 212 yards versus the Seahawks on November 19, 2006.
Interpreted as:
49ers player with most rushing yards in a regular-season game| NAME | RUSH YDS | DATE | TM | OPP | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | F. Gore | 212 | 11/19/2006 | vs | 24 | 8.8 | 0 | 26 | 4 | 4 | 6.5 | 0 | ||
| 2 | | F. Gore | 207 | 9/20/2009 | vs | 16 | 12.9 | 2 | 39 | 5 | 5 | 7.8 | 0 | ||
| 3 |  | C. Garner | 201 | 9/24/2000 | @ | 36 | 5.6 | 1 | 34 | 3 | 4 | 11.3 | 0 | ||
| 4 | | G. Hearst | 198 | 12/14/1998 | vs | 24 | 8.3 | 1 | 0 | 0 | 0 | ||||
| 5 | | D. Williams | 194 | 10/31/1976 | @ | 34 | 5.7 | 3 | 8 | 1 | 8.0 | 0 | |||
| 6 |  | C. Hyde | 193 | 12/11/2016 | vs | 17 | 11.4 | 0 | 7 | 1 | 1 | 7.0 | 1 | ||
| 7 | | R. Craig | 190 | 10/16/1988 | @ | 22 | 8.6 | 3 | 12 | 5 | 2.4 | 0 | |||
| 8 | | W. Jackson | 190 | 11/27/1977 | vs | 16 | 11.9 | 2 | 5 | 1 | 5.0 | 0 | |||
| 9 | | G. Hearst | 187 | 9/6/1998 | vs | 20 | 9.4 | 2 | 38 | 2 | 19.0 | 0 | |||
| 10 |  | J. Wilson Jr. | 183 | 12/26/2020 | @ | 22 | 8.3 | 0 | 21 | 1 | 2 | 21.0 | 1 | ||
| 11 | | D. Williams | 180 | 11/7/1976 | vs | 23 | 7.8 | 2 | 99 | 4 | 24.8 | 1 | |||
| 12 | | J. Perry | 174 | 11/2/1958 | vs | 13 | 13.4 | 1 | 22 | 2 | 11.0 | 0 | |||
| 13 | | H. McElhenny | 170 | 10/5/1952 | @ | 7 | 24.3 | 1 | 33 | 1 | 33.0 | 1 | |||
| 14 | | C. Hyde | 168 | 9/14/2015 | vs | 26 | 6.5 | 2 | 14 | 2 | 2 | 7.0 | 0 | ||
| 15 | | J.D. Smith | 168 | 11/26/1961 | vs | 28 | 6.0 | 2 | 0 | 0 | 0 | ||||
| 16 | | F. Gore | 167 | 12/14/2009 | vs | 25 | 6.7 | 1 | 10 | 2 | 3 | 5.0 | 0 | ||
| 17 | | C. Garner | 166 | 11/7/1999 | vs | 20 | 8.3 | 0 | 33 | 3 | 7 | 11.0 | 0 | ||
| 18 | | G. Hearst | 166 | 11/30/1998 | vs | 20 | 8.3 | 1 | 7 | 2 | 3.5 | 0 | |||
| 19 | | R. Watters | 163 | 11/22/1992 | @ | 26 | 6.3 | 2 | 16 | 3 | 5.3 | 0 | |||
| 20 | | R. Craig | 162 | 11/6/1988 | @ | 26 | 6.2 | 1 | 0 | 1 | 0.0 | 0 | |||
| 21 | | K. Willard | 162 | 12/15/1968 | @ | 25 | 6.5 | 2 | 16 | 2 | 8.0 | 0 | |||
| 22 | | F. Gore | 159 | 11/12/2006 | @ | 22 | 7.2 | 1 | 14 | 2 | 3 | 7.0 | 0 | ||
| 23 | | H. McElhenny | 159 | 11/23/1958 | @ | 22 | 7.2 | 1 | 19 | 2 | 9.5 | 0 | |||
| 24 | | F. Gore | 158 | 12/20/2014 | vs | 26 | 6.1 | 1 | 0 | 0 | 0 | 0 | |||
| 25 | | W. Jackson | 156 | 11/29/1976 | vs | 30 | 5.2 | 1 | 0 | 0 | 0 | ||||
STL
NYJ
RAM
WAS
DAL
PHXResults may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.
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More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |