The San Francisco 49ers are 5-3 in the regular-season and playoffs versus the Chargers at home all-time.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/17/1972 | 1-0 | vs | W 34-3 | 1.000 | 4 | 18 | 295 | 258 | ||||
| 2 | | 49ers | 12/11/1982 | 0-1 | vs | L 37-41 | .000 | 5 | 29 | 465 | 538 | ||||
| 3 | | 49ers | 9/8/1991 | 1-0 | vs | W 34-14 | 1.000 | 4 | 24 | 458 | 326 | 36.4 | 0.0 | ||
| 4 | | 49ers | 1/29/1995 | 1-0 | vs | W 49-26 | 1.000 | 7 | 28 | 455 | 354 | 53.8 | |||
| 5 | | 49ers | 11/23/1997 | 1-0 | vs | W 17-10 | 1.000 | 2 | 19 | 339 | 203 | 30.8 | |||
| 6 | | 49ers | 10/15/2006 | 0-1 | vs | L 19-48 | .000 | 2 | 15 | 274 | 421 | 36.4 | 0.0 | ||
| 7 | | 49ers | 12/20/2014 | 0-1 | vs | L 35-38 | .000 | 5 | 21 | 447 | 446 | 45.5 | 0.0 | ||
| 8 | | 49ers | 11/13/2022 | 1-0 | vs | W 22-16 | 1.000 | 2 | 22 | 387 | 238 | 52.9 | 100.0 | ||
| Average | .625 | 3.9 | 22.0 | 390.0 | 348.0 | 6.3 | |||||||||
| Total | 5-3 | .625 | 31 | 176 | 3,120 | 2,784 | 25.0 |
More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
