The San Francisco 49ers have a record of 19-27 in the regular-season and playoffs versus the Colts all-time.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 11/29/1953 | 1-0 | @ | W 38-21 | 1.000 | 5 | 16 | 368 | 234 | ||||
| 2 | | 49ers | 12/13/1953 | 1-0 | vs | W 45-14 | 1.000 | 6 | 31 | 597 | 136 | ||||
| 3 | | 49ers | 11/28/1954 | 0-1 | @ | L 13-17 | .000 | 1 | 22 | 325 | 297 | ||||
| 4 | | 49ers | 12/11/1954 | 1-0 | vs | W 10-7 | 1.000 | 1 | 18 | 292 | 273 | ||||
| 5 | | 49ers | 11/27/1955 | 0-1 | @ | L 14-26 | .000 | 2 | 14 | 296 | 392 | ||||
| 6 | | 49ers | 12/11/1955 | 1-0 | vs | W 35-24 | 1.000 | 5 | 19 | 325 | 327 | ||||
| 7 | | 49ers | 12/2/1956 | 1-0 | @ | W 20-17 | 1.000 | 3 | 16 | 360 | 302 | ||||
| 8 | | 49ers | 12/16/1956 | 1-0 | vs | W 30-17 | 1.000 | 4 | 20 | 303 | 336 | ||||
| 9 | | 49ers | 11/24/1957 | 0-1 | @ | L 21-27 | .000 | 3 | 26 | 410 | 455 | ||||
| 10 | | 49ers | 12/8/1957 | 1-0 | vs | W 17-13 | 1.000 | 2 | 23 | 326 | 370 | ||||
| 11 | | 49ers | 11/30/1958 | 0-1 | @ | L 27-35 | .000 | 4 | 22 | 313 | 415 | ||||
| 12 | | 49ers | 12/14/1958 | 1-0 | vs | W 21-12 | 1.000 | 3 | 23 | 368 | 289 | ||||
| 13 | | 49ers | 11/22/1959 | 0-1 | @ | L 14-45 | .000 | 2 | 3 | 133 | 439 | ||||
| 14 | | 49ers | 12/5/1959 | 0-1 | vs | L 14-34 | .000 | 2 | 13 | 254 | 395 | ||||
| 15 | | 49ers | 11/27/1960 | 1-0 | @ | W 30-22 | 1.000 | 3 | 18 | 356 | 428 | ||||
| 16 | | 49ers | 12/18/1960 | 1-0 | vs | W 34-10 | 1.000 | 4 | 19 | 251 | 177 | ||||
| 17 | | 49ers | 12/3/1961 | 0-1 | @ | L 17-20 | .000 | 2 | 17 | 309 | 346 | ||||
| 18 | | 49ers | 12/16/1961 | 0-1 | vs | L 24-27 | .000 | 3 | 25 | 355 | 366 | ||||
| 19 | | 49ers | 10/7/1962 | 1-0 | @ | W 21-13 | 1.000 | 3 | 25 | 335 | 261 | ||||
| 20 | | 49ers | 11/4/1962 | 0-1 | vs | L 3-22 | .000 | 0 | 11 | 151 | 311 | ||||
| 21 | | 49ers | 9/22/1963 | 0-1 | vs | L 14-20 | .000 | 2 | 14 | 194 | 395 | ||||
| 22 | | 49ers | 10/13/1963 | 0-1 | @ | L 3-20 | .000 | 0 | 5 | 120 | 302 | ||||
| 23 | | 49ers | 11/1/1964 | 0-1 | @ | L 7-37 | .000 | 1 | 14 | 221 | 384 | ||||
| 24 | | 49ers | 11/29/1964 | 0-1 | vs | L 3-14 | .000 | 0 | 15 | 246 | 239 | ||||
| 25 | | 49ers | 10/3/1965 | 0-1 | @ | L 24-27 | .000 | 3 | 15 | 352 | 341 | ||||
| Average | .413 | 2.5 | 18.5 | 311.8 | 343.1 | ||||||||||
| Total | 19-27 | .413 | 117 | 850 | 14,343 | 15,781 | |||||||||
BALMore 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
