The San Francisco 49ers have a 6-5 record against the AFC South in the regular-season and playoffs since 2017.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 10/8/2017 | 0-1 |  SF | @ |  IND | L 23-26 | .000 | 2 | 23 | 402 | 447 | 28.6 | 100.0 |
| 2 | | 49ers | 12/10/2017 | 1-0 | SF | @ |  HOU | W 26-16 | 1.000 | 2 | 20 | 416 | 311 | 18.2 | |
| 3 | | 49ers | 12/17/2017 | 1-0 | SF | vs |  TEN | W 25-23 | 1.000 | 1 | 23 | 414 | 328 | 50.0 | |
| 4 | | 49ers | 12/24/2017 | 1-0 | SF | vs |  JAX | W 44-33 | 1.000 | 6 | 26 | 369 | 472 | 66.7 | |
| 5 | | 49ers | 10/24/2021 | 0-1 | SF | vs | IND | L 18-30 | .000 | 2 | 13 | 280 | 295 | 9.1 | |
| 6 | | 49ers | 11/21/2021 | 1-0 | SF | @ | JAX | W 30-10 | 1.000 | 3 | 25 | 333 | 200 | 50.0 | 100.0 |
| 7 | | 49ers | 12/23/2021 | 0-1 | SF | @ | TEN | L 17-20 | .000 | 2 | 22 | 389 | 278 | 37.5 | 50.0 |
| 8 | | 49ers | 1/2/2022 | 1-0 | SF | vs | HOU | W 23-7 | 1.000 | 2 | 19 | 416 | 222 | 38.5 | 0.0 |
| 9 | | 49ers | 11/12/2023 | 1-0 | SF | @ | JAX | W 34-3 | 1.000 | 4 | 20 | 437 | 221 | 33.3 | 50.0 |
| 10 | | 49ers | 9/28/2025 | 0-1 | SF | vs | JAX | L 21-26 | .000 | 2 | 22 | 389 | 325 | 61.5 | 0.0 |
| 11 | | 49ers | 10/26/2025 | 0-1 | SF | @ | HOU | L 15-26 | .000 | 2 | 12 | 223 | 475 | 33.3 | 0.0 |
| Average | .545 | 2.5 | 20.5 | 369.8 | 324.9 | 40.2 | 6.5 | ||||||||
| Total | 6-5 | .545 | 28 | 225 | 4,068 | 3,574 | 40.2 | 45.5 |
More 49ers Stats
Team Rankings
PPG
20.0
26th
OPP PPG
20.5
8th
RUSH YDS/G
89.4
30th
PASS YDS/G
272.9
2nd
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