The San Francisco 49ers have a record of 6-4 in Week 1 between September 17, 2016 and September 17, 2026.
- Regular season
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/10/2017 | 0-1 | vs | L 3-23 | .000 | 0 | 13 | 217 | 287 | 18.2 | 25.0 | ||
| 2 | | 49ers | 9/9/2018 | 0-1 | @ | L 16-24 | .000 | 1 | 20 | 327 | 343 | 38.5 | |||
| 3 | | 49ers | 9/8/2019 | 1-0 | @ | W 31-17 | 1.000 | 3 | 17 | 256 | 295 | 38.5 | |||
| 4 | | 49ers | 9/13/2020 | 0-1 | vs | L 20-24 | .000 | 2 | 18 | 366 | 404 | 18.2 | 0.0 | ||
| 5 | | 49ers | 9/12/2021 | 1-0 | @ | W 41-33 | 1.000 | 5 | 21 | 442 | 430 | 33.3 | |||
| 6 | | 49ers | 9/11/2022 | 0-1 | @ | L 10-19 | .000 | 1 | 17 | 331 | 204 | 47.1 | 0.0 | ||
| 7 | | 49ers | 9/10/2023 | 1-0 | @ | W 30-7 | 1.000 | 3 | 22 | 391 | 239 | 46.2 | 100.0 | ||
| 8 | | 49ers | 9/9/2024 | 1-0 | vs | W 32-19 | 1.000 | 2 | 24 | 401 | 266 | 46.2 | |||
| 9 | | 49ers | 9/7/2025 | 1-0 | @ | W 17-13 | 1.000 | 2 | 24 | 384 | 230 | 50.0 | 100.0 | ||
| 10 | | 49ers | 9/10/2026 | 1-0 | @ | W 27-7 | 1.000 | 3 | 23 | 379 | 290 | 58.3 | |||
| Average | .600 | 2.2 | 19.9 | 349.4 | 298.8 | 40.5 | 0.1 | ||||||||
| Total | 6-4 | .600 | 22 | 199 | 3,494 | 2,988 | 40.5 | 36.4 |
SF
CAR
MIN
TB
ARI
DET
CHI
PIT
NYJ
SEA
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More 49ers Stats
Team Leaders 
PASS
205
Purdy
RUSH
68
McCaffrey
REC
50
Robinson
Team Rankings
PPG
27.0
13th
OPP PPG
7.0
1st
RUSH YDS/G
174.0
4th
PASS YDS/G
205.0
18th
MIA
DEN
WAS
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
| NFC North | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 | |
| NFC South | W | L | T | PCT |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
| NFC West | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 |
Giants
Eagles
Cowboys
Bears
Packers
Falcons
Saints| AFC East | W | L | T | PCT |
|---|---|---|---|---|
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
| AFC North | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 | |
| AFC South | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
| AFC West | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 |
Bills
Patriots
Ravens
Bengals
Browns
Jaguars
Texans
Titans
Colts
Chiefs
Raiders
Chargers