The San Francisco 49ers have a record of 38-31 in the regular season and playoffs against the Cardinals all-time.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 11/18/1951 | 0-1 | vs | L 21-27 | .000 | 3 | 26 | 379 | 437 | ||||
| 2 | | 49ers | 9/29/1957 | 0-1 | vs | L 10-20 | .000 | 1 | 16 | 324 | 346 | ||||
| 3 | | 49ers | 11/25/1962 | 1-0 | @ | W 24-17 | 1.000 | 3 | 15 | 215 | 314 | ||||
| 4 | | 49ers | 9/27/1964 | 0-1 | vs | L 13-23 | .000 | 1 | 14 | 235 | 296 | ||||
| 5 | | 49ers | 9/22/1968 | 1-0 | vs | W 35-17 | 1.000 | 5 | 22 | 395 | 228 | ||||
| 6 | | 49ers | 10/24/1971 | 1-0 | @ | W 26-14 | 1.000 | 2 | 16 | 366 | 284 | ||||
| 7 | | 49ers | 10/6/1974 | 0-1 | vs | L 9-34 | .000 | 1 | 12 | 306 | 407 | ||||
| 8 | | 49ers | 10/31/1976 | 0-1 | @ | L 20-23 | .000 | 3 | 23 | 382 | 373 | ||||
| 9 | | 49ers | 11/12/1978 | 0-1 | vs | L 10-16 | .000 | 1 | 16 | 264 | 335 | ||||
| 10 | | 49ers | 12/2/1979 | 0-1 | @ | L 10-13 | .000 | 1 | 16 | 290 | 286 | ||||
| 11 | | 49ers | 9/14/1980 | 1-0 | vs | W 24-21 | 1.000 | 3 | 19 | 392 | 342 | ||||
| 12 | | 49ers | 11/21/1982 | 1-0 | @ | W 31-20 | 1.000 | 4 | 22 | 448 | 254 | ||||
| 13 | | 49ers | 9/18/1983 | 1-0 | @ | W 42-27 | 1.000 | 6 | 24 | 527 | 385 | ||||
| 14 | | 49ers | 11/9/1986 | 1-0 | vs | W 43-17 | 1.000 | 5 | 23 | 460 | 364 | ||||
| 15 | | 49ers | 10/18/1987 | 1-0 | vs | W 34-28 | 1.000 | 5 | 28 | 448 | 324 | ||||
| 16 | | 49ers | 11/6/1988 | 0-1 | @ | L 23-24 | .000 | 2 | 22 | 357 | 355 | ||||
| 17 | | 49ers | 11/17/1991 | 1-0 | vs | W 14-10 | 1.000 | 2 | 22 | 257 | 176 | 60.0 | |||
| 18 | | 49ers | 11/1/1992 | 0-1 | @ | L 14-24 | .000 | 2 | 19 | 330 | 342 | 14.3 | 0.0 | ||
| 19 | | 49ers | 10/24/1993 | 1-0 | vs | W 28-14 | 1.000 | 4 | 26 | 428 | 429 | 50.0 | |||
| 20 | | 49ers | 9/27/1999 | 1-0 | @ | W 24-10 | 1.000 | 3 | 18 | 322 | 250 | 43.8 | |||
| 21 | | 49ers | 10/1/2000 | 1-0 | vs | W 27-20 | 1.000 | 3 | 18 | 345 | 365 | 43.8 | |||
| 22 | | 49ers | 10/27/2002 | 1-0 | vs | W 38-28 | 1.000 | 5 | 18 | 357 | 420 | 50.0 | 100.0 | ||
| 23 | | 49ers | 12/21/2002 | 1-0 | @ | W 17-14 | 1.000 | 2 | 21 | 358 | 184 | 55.0 | 50.0 | ||
| 24 | | 49ers | 10/26/2003 | 0-1 | @ | L 13-16 | .000 | 2 | 15 | 255 | 314 | 50.0 | |||
| 25 | | 49ers | 12/7/2003 | 1-0 | vs | W 50-14 | 1.000 | 7 | 30 | 496 | 210 | 50.0 | 0.0 | ||
| Average | .551 | 2.8 | 19.8 | 344.4 | 337.6 | ||||||||||
| Total | 38-31 | .551 | 194 | 1,363 | 23,762 | 23,294 | |||||||||
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More 49ers Stats
Team Leaders 
PASS
205
Purdy
RUSH
68
McCaffrey
REC
50
Robinson
Team Rankings
PPG
27.0
1st
OPP PPG
7.0
1st
RUSH YDS/G
174.0
1st
PASS YDS/G
205.0
1st
Seahawks
Rams
MIA
DEN
WAS
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
| NFC North | W | L | T | PCT |
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
| NFC South | W | L | T | PCT |
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
| NFC West | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 0 | 0 | ||
0 | 1 | 0 | .000 |
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