49ers vs afc ats home favorite since 2017

The San Francisco 49ers have a record of 7-10 against the spread as favorites against the AFC at home since 2017.

	TEAM	DATE	ATS	TM			OPP		RESULT	SPREAD	ATS DIFF	O/U	O/U DIFF	TD	1DWN	OFF	OPP OFF	3DWN%	4DWN%
1	49ers	12/17/2017	0-1	SF	-135	vs	TEN	+125	W 25-23	-2.5	-0.5 (N)	44.5	+3.5 (O)	1	23	414	328	50.0
2	49ers	9/22/2019	0-1	SF	-301	vs	PIT	+242	W 24-20	-6.5	-2.5 (N)	44	0 (P)	3	26	436	239	54.5
3	49ers	10/7/2019	1-0	SF	-227	vs	CLE	+187	W 31-3	-4.5	+23.5 (Y)	48	-14 (U)	4	22	446	180	37.5	100.0
4	49ers	10/11/2020	0-1	SF	-390	vs	MIA	+314	L 17-43	-8.5	-34.5 (N)	50.5	+9.5 (O)	2	19	259	436	20.0	0.0
5	49ers	12/7/2020	0-1	SF	-124	vs	BUF	+105	L 24-34	-1.5	-11.5 (N)	48	+10 (O)	3	24	402	449	54.5	0.0
6	49ers	10/24/2021	0-1	SF	-176	vs	IND	+147	L 18-30	-3.5	-15.5 (N)	41.5	+6.5 (O)	2	13	280	295	9.1
7	49ers	1/2/2022	1-0	SF	-740	vs	HOU	+507	W 23-7	-13.5	+2.5 (Y)	44.5	-14.5 (U)	2	19	416	222	38.5	0.0
8	49ers	11/13/2022	0-1	SF	-361	vs	LAC	+284	W 22-16	-8	-2 (N)	45.5	-7.5 (U)	2	22	387	238	52.9	100.0
9	49ers	12/4/2022	1-0	SF	-233	vs	MIA	+191	W 33-17	-5	+11 (Y)	46	+4 (O)	3	24	351	308	42.1	50.0
10	49ers	10/29/2023	0-1	SF	-211	vs	CIN	+173	L 17-31	-4	-18 (N)	44	+4 (O)	2	24	460	400	55.6
11	49ers	12/25/2023	0-1	SF	-296	vs	BAL	+238	L 19-33	-6.5	-20.5 (N)	47	+5 (O)	2	21	429	343	42.9	33.3
12	49ers	9/9/2024	1-0	SF	-195	vs	NYJ	+163	W 32-19	-3.5	+9.5 (Y)	43	+8 (O)	2	24	401	266	46.2
13	49ers	9/29/2024	1-0	SF	-585	vs	NE	+432	W 30-13	-10.5	+6.5 (Y)	42.5	+0.5 (O)	3	19	431	216	53.8
14	49ers	10/20/2024	0-1	SF	-143	vs	KC	+121	L 18-28	-2.5	-12.5 (N)	48	-2 (U)	2	19	310	329	18.2	100.0
15	49ers	9/28/2025	0-1	SF	-178	vs	JAX	+144	L 21-26	-3.5	-8.5 (N)	45.5	+1.5 (O)	2	22	389	325	61.5	0.0
16	49ers	12/14/2025	1-0	SF	-952	vs	TEN	+633	W 37-24	-12.5	+0.5 (Y)	44.5	+16.5 (O)	4	28	430	306	60.0	100.0
17	49ers	9/20/2026	1-0	SF	-980	vs	MIA	+610	W 35-13	-13.5	+8.5 (Y)	45.5	+2.5 (O)	5	23	382	284	71.4
	Average		2.4											2.6	21.9	389.6	303.8	45.2	0.0
	Total		7-10											44	372	6,623	5,164	45.2	40.0

StatMuse has team, game-level data for spread records going back to the 1979 season.

More NFL News

Raiders' pass rush helping to drive 2-0 start

Sep 23, 2026

Saints place Banks on IR, reach injury settlement with Estime and sign long snapper Adomitis

Sep 23, 2026

Bills defensive lineman T.J. Sanders out indefinitely after having appendectomy

Sep 23, 2026

Keenum practices amid murky situation for the Chicago Bears at QB

Sep 23, 2026

Jets WR Arian Smith has season-ending ACL injury and DL David Onyemata out after core muscle surgery

Sep 23, 2026

Colts WR Alec Pierce will be placed on injured reserve after aggravating left heel injury

Sep 23, 2026

More 49ers Stats

Team Leaders

PASS

492

Purdy

RUSH

91

McCaffrey

REC

103

Evans

Team Rankings

PPG

31.0

4th

OPP PPG

10.0

3rd

RUSH YDS/G

134.5

8th

PASS YDS/G

246.0

10th

2026 Division Standings

TEAM	W	L	PCT
49ers	2	0	1.000
Seahawks	2	0	1.000
Cardinals	1	1	.500
Rams	1	1	.500

Schedule

DATE	MATCHUP			TIME (ET)
Sun 9/27	ARI	@	SF	4:05 PM
Sun 10/4	DEN	@	SF	4:25 PM
Sun 10/11	SF	@	SEA	4:25 PM
Mon 10/19	WAS	@	SF	8:15 PM
Sun 10/25	SF	@	ATL	1:00 PM

Last Game

Dolphins

0 - 2

Final

49ers

2 - 0

Sun 20 Sep 2026

NFL 2026 Leaders

Pass Yards Leaders

662

Shough

648

Young

627

Stroud

Rush Yards Leaders

290

Walker

212

Henry

208

Gibbs

Rec Yards Leaders

277

Smith-Njigba

268

Olave

225

Kincaid

Pass TD Leaders

6

Young

6

Prescott

6

Goff

Rush TD Leaders

4

Taylor

4

Allen

4

Henry

Rec TD Leaders

4

Smith-Njigba

4

St. Brown

3

Watson

QB Rating Leaders

127.3

Lock

125.9

Dart

125.8

Allen

Sack Leaders

4.0

Rousseau

3.5

Watt

3.0

Hutchinson

NFL 2026 Rankings

PPG Rankings

38.5

35.5

32.0

31.0

Opp PPG Rankings

8.0

8.5

10.0

12.5

13.5

15.0

Total Yards Rankings

457.5

427.5

424.5

409.0

385.5

Rush Yards Rankings

212.5

186.0

157.0

155.0

144.5

142.5

Pass Yards Rankings

331.0

324.0

313.5

291.0

283.0

279.5

Sack Leaders

8.0

7.0

NFL Fantasy 2026

Fantasy RB Rankings

49

Henry

48.9

Walker

47.3

Taylor

Fantasy WR Rankings

51.7

Smith-Njigba

44.9

St. Brown

37.7

Lamb

Fantasy TE Rankings

28.5

Kincaid

25.6

McBride

23.2

Kelce

Fantasy K Rankings

31

McPherson

27

McLaughlin

24

Butker

NFL 2026 Betting

Best Record ATS

2-0

Worst Record ATS

0-2

NFL 2026 Standings

NFC East	W	L	T	PCT
Eagles	2	0	0	1.000
Giants	1	1	0	.500
Cowboys	1	1	0	.500
Commanders	0	2	0	.000
NFC North	W	L	T	PCT
Vikings	2	0	0	1.000
Lions	1	1	0	.500
Bears	1	1	0	.500
Packers	1	1	0	.500
NFC South	W	L	T	PCT
Panthers	1	1	0	.500
Saints	1	1	0	.500
Buccaneers	0	2	0	.000
Falcons	0	2	0	.000
NFC West	W	L	T	PCT
Seahawks	2	0	0	1.000
49ers	2	0	0	1.000
Rams	1	1	0	.500
Cardinals	1	1	0	.500

AFC East	W	L	T	PCT
Bills	2	0	0	1.000
Patriots	1	1	0	.500
Jets	1	1	0	.500
Dolphins	0	2	0	.000
AFC North	W	L	T	PCT
Bengals	2	0	0	1.000
Ravens	1	1	0	.500
Steelers	1	1	0	.500
Browns	1	1	0	.500
AFC South	W	L	T	PCT
Jaguars	1	1	0	.500
Titans	0	2	0	.000
Texans	0	2	0	.000
Colts	0	2	0	.000
AFC West	W	L	T	PCT
Chiefs	2	0	0	1.000
Raiders	2	0	0	1.000
Broncos	1	1	0	.500
Chargers	0	2	0	.000

NFL 2026 Scores & Schedule

Scores

DATE	MATCHUP			SCORE
Wed 9/9	NE	@	SEA	10-13
Thu 9/10	SF	@	LAR	27-7
Sun 9/13	CHI	@	CAR	59-37
Sun 9/13	BAL	@	IND	41-23
Sun 9/13	ATL	@	PIT	13-20

Schedule

DATE	MATCHUP			TIME (ET)
Thu 9/24	ATL	@	GB	8:15 PM
Sun 9/27	KC	@	MIA	1:00 PM
Sun 9/27	CAR	@	CLE	1:00 PM
Sun 9/27	TEN	@	NYG	1:00 PM
Sun 9/27	NE	@	JAX	1:00 PM

The San Francisco 49ers have a record of 7-10 against the spread as favorites against the AFC at home since 2017.

Related Searches

More NFL News

More 49ers Stats

492

91

103

NFL 2026 Leaders

662

648

627

290

212

208

277

268

225

6

6

6

4

4

4

4

4

3

127.3

125.9

125.8

4.0

3.5

3.0

NFL 2026 Rankings

NFL Fantasy 2026

49

48.9

47.3

51.7

44.9

37.7

28.5

25.6

23.2

31

27

24

NFL 2026 Betting

NFL 2026 Standings

NFL 2026 Scores & Schedule

Scores

Schedule