The San Francisco 49ers have a record of 6-2 against the spread in their last 20 games versus the Jaguars.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/12/1999 | 0-1 |  SF | @ |  JAX | L 3-41 | +6 | -32 (N) | 49.5 | -5.5 (U) | 0 | 11 | 203 | 344 | 7.1 | 50.0 | ||
| 2 | | 49ers | 12/18/2005 | 1-0 | SF | @ | JAX | L 9-10 | +15.5 | +14.5 (Y) | 37.5 | -18.5 (U) | 0 | 11 | 217 | 336 | 7.7 | 0.0 | ||
| 3 | | 49ers | 11/29/2009 | 1-0 | SF | -175 | vs | JAX | +155 | W 20-3 | -3.5 | +13.5 (Y) | 41.5 | -18.5 (U) | 2 | 15 | 284 | 357 | 50.0 | 100.0 |
| 4 | | 49ers | 10/27/2013 | 1-0 | SF | -1800 | @ | JAX | +1000 | W 42-10 | -15 | +17 (Y) | 40 | +12 (O) | 6 | 25 | 398 | 318 | 66.7 | 100.0 |
| 5 | | 49ers | 12/24/2017 | 1-0 | SF | +190 | vs | JAX | -210 | W 44-33 | +4 | +15 (Y) | 43 | +34 (O) | 6 | 26 | 369 | 472 | 66.7 | |
| 6 | | 49ers | 11/21/2021 | 1-0 | SF | -290 | @ | JAX | +233 | W 30-10 | -6.5 | +13.5 (Y) | 45.5 | -5.5 (U) | 3 | 25 | 333 | 200 | 50.0 | 100.0 |
| 7 | | 49ers | 11/12/2023 | 1-0 | SF | -172 | @ | JAX | +144 | W 34-3 | -3 | +28 (Y) | 44.5 | -7.5 (U) | 4 | 20 | 437 | 221 | 33.3 | 50.0 |
| 8 | | 49ers | 9/28/2025 | 0-1 | SF | -178 | vs | JAX | +144 | L 21-26 | -3.5 | -8.5 (N) | 45.5 | +1.5 (O) | 2 | 22 | 389 | 325 | 61.5 | 0.0 |
| Average | 9.4 | 2.9 | 19.4 | 328.8 | 321.6 | 42.3 | 8.6 | |||||||||||||
| Total | 6-2 | 23 | 155 | 2,630 | 2,573 | 42.3 | 60.0 |
StatMuse has team, game-level data for spread records going back to the 1979 season.
More 49ers Stats
Team Rankings
PPG
20.0
23rd
OPP PPG
18.8
7th
RUSH YDS/G
88.0
28th
PASS YDS/G
287.3
2nd
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| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 4 | 0 | 0 | 1.000 |
 Commanders | 2 | 2 | 0 | .500 |
| NFC North | W | L | T | PCT |
 Lions | 3 | 1 | 0 | .750 |
 Packers | 2 | 1 | 1 | .625 |
| NFC South | W | L | T | PCT |
 Buccaneers | 3 | 1 | 0 | .750 |
 Falcons | 2 | 2 | 0 | .500 |
| NFC West | W | L | T | PCT |
| 49ers | 3 | 1 | 0 | .750 |
 Seahawks | 3 | 1 | 0 | .750 |
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