Between the 2010 and 2020 seasons, LeSean McCoy rushed for the most yards in the AFC East, with 3,814 yards.
| NAME | RUSH YDS | GP | ATT | YPC | RUSH YDS/G | RUSH TD | REC YDS | REC | TRG | AVG | REC YDS/G | REC TD | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | L. McCoy | 3,814 | 57 | 885 | 4.3 | 66.9 | 25 | 1,334 | 175 | 230 | 7.6 | 23.4 | 5 |
| 2 |  | F. Jackson | 3,713 | 66 | 854 | 4.3 | 56.3 | 25 | 1,762 | 217 | 302 | 8.1 | 26.7 | 5 |
| 3 | | B. Powell | 3,675 | 109 | 850 | 4.3 | 33.7 | 15 | 1,600 | 211 | 309 | 7.6 | 14.7 | 5 |
| 4 | | C.J. Spiller | 3,330 | 74 | 671 | 5.0 | 45.0 | 12 | 1,202 | 159 | 206 | 7.6 | 16.2 | 6 |
| 5 | | C. Ivory | 3,109 | 59 | 742 | 4.2 | 52.7 | 17 | 555 | 63 | 92 | 8.8 | 9.4 | 2 |
| 6 |  | L. Miller | 2,930 | 61 | 638 | 4.6 | 48.0 | 19 | 887 | 117 | 153 | 7.6 | 14.5 | 3 |
| 7 |  | L. Blount | 2,917 | 49 | 677 | 4.3 | 59.5 | 34 | 137 | 19 | 24 | 7.2 | 2.8 | 1 |
| 8 | | S. Ridley | 2,907 | 60 | 685 | 4.2 | 48.5 | 22 | 144 | 27 | 41 | 5.3 | 2.4 | 0 |
| 9 | | S. Greene | 2,883 | 47 | 714 | 4.0 | 61.3 | 16 | 482 | 65 | 96 | 7.4 | 10.3 | 0 |
| 10 |  | S. Michel | 2,292 | 38 | 535 | 4.3 | 60.3 | 14 | 258 | 26 | 40 | 9.9 | 6.8 | 1 |
| 11 | | R. Bush | 2,069 | 44 | 455 | 4.5 | 47.0 | 13 | 678 | 85 | 113 | 8.0 | 15.4 | 3 |
| 12 |  | F. Gore | 1,974 | 45 | 509 | 3.9 | 43.9 | 4 | 313 | 41 | 51 | 7.6 | 7.0 | 1 |
| 13 |  | J. Ajayi | 1,924 | 31 | 447 | 4.3 | 62.1 | 9 | 308 | 48 | 66 | 6.4 | 9.9 | 0 |
| 14 | | B. Green-Ellis | 1,675 | 32 | 410 | 4.1 | 52.3 | 24 | 244 | 21 | 29 | 11.6 | 7.6 | 0 |
| 15 |  | T. Taylor | 1,575 | 44 | 283 | 5.6 | 35.8 | 14 | 4 | 1 | 1 | 4.0 | 0.1 | 0 |
| 16 |  | J. Allen | 1,562 | 44 | 300 | 5.2 | 35.5 | 25 | 12 | 1 | 2 | 12.0 | 0.3 | 1 |
| 17 |  | K. Drake | 1,532 | 54 | 333 | 4.6 | 28.4 | 9 | 936 | 116 | 164 | 8.1 | 17.3 | 6 |
| 18 | | D. Thomas | 1,480 | 52 | 409 | 3.6 | 28.5 | 10 | 412 | 55 | 74 | 7.5 | 7.9 | 3 |
| 19 |  | R. Fitzpatrick | 1,475 | 99 | 321 | 4.6 | 14.9 | 9 | 0 | 1 | 1 | 0.0 | 0.0 | 0 |
| 20 |  | D. Singletary | 1,462 | 28 | 307 | 4.8 | 52.2 | 4 | 463 | 67 | 91 | 6.9 | 16.5 | 2 |
| 21 |  | D. Lewis | 1,413 | 30 | 293 | 4.8 | 47.1 | 8 | 696 | 85 | 109 | 8.2 | 23.2 | 5 |
| 22 | | M. Gillislee | 1,248 | 32 | 258 | 4.8 | 39.0 | 16 | 94 | 16 | 19 | 5.9 | 2.9 | 1 |
| 23 |  | J. White | 1,240 | 92 | 309 | 4.0 | 13.5 | 10 | 3,184 | 369 | 497 | 8.6 | 34.6 | 25 |
| 24 |  | R. Tannehill | 1,210 | 88 | 248 | 4.9 | 13.8 | 6 | 8 | 3 | 3 | 2.7 | 0.1 | 1 |
| 25 | | D. Woodhead | 1,199 | 46 | 250 | 4.8 | 26.1 | 10 | 982 | 92 | 130 | 10.7 | 21.3 | 4 |
StatMuse has season-level data for rushing yards going back to the 1932 season.
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More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |