Since 2000, the Arizona Cardinals have their lowest point differential in a home game against the Seahawks on September 14, 2003, with a -38-point differential.
Interpreted as:
arizona cardinals largest home loss in a regular-season game since 2000| TEAM | DIFF | DATE | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Cardinals | -38 | 9/14/2003 | vs | L 0-38 | 0 | 18 | 286 | 323 | 55.6 | 0.0 | ||
| 2 | | Cardinals | -35 | 10/18/2018 | vs | L 10-45 | 1 | 14 | 223 | 309 | 28.6 | 0.0 | ||
| 3 | | Cardinals | -30 | 1/3/2016 | vs | L 6-36 | 1 | 16 | 232 | 354 | 41.7 | 0.0 | ||
| 4 | | Cardinals | -29 | 12/21/2014 | vs | L 6-35 | 0 | 17 | 216 | 596 | 20.0 | 100.0 | ||
| 5 | | Cardinals | -28 | 12/7/2025 | vs | L 17-45 | 2 | 17 | 314 | 530 | 33.3 | 0.0 | ||
| 6 | | Cardinals | -28 | 9/29/2024 | vs | L 14-42 | 2 | 17 | 296 | 449 | 36.4 | 66.7 | ||
| 7 | | Cardinals | -28 | 11/21/2022 | vs | L 10-38 | 1 | 19 | 314 | 387 | 50.0 | 0.0 | ||
| 8 | | Cardinals | -27 | 12/1/2019 | vs | L 7-34 | 1 | 13 | 198 | 549 | 15.4 | 50.0 | ||
| 9 | | Cardinals | -26 | 1/3/2010 | vs | L 7-33 | 1 | 13 | 187 | 345 | 50.0 | |||
| 10 | | Cardinals | -26 | 9/24/2000 | vs | L 3-29 | 0 | 12 | 209 | 455 | 42.9 | 0.0 | ||
| 11 | | Cardinals | -24 | 11/14/2021 | vs | L 10-34 | 1 | 11 | 169 | 341 | 30.8 | 0.0 | ||
| 12 | | Cardinals | -24 | 11/26/2000 | vs | L 7-31 | 1 | 14 | 267 | 371 | 16.7 | 0.0 | ||
| 13 | | Cardinals | -23 | 11/26/2023 | vs | L 14-37 | 2 | 19 | 292 | 457 | 35.3 | 66.7 | ||
| 14 | | Cardinals | -23 | 9/11/2022 | vs | L 21-44 | 3 | 18 | 282 | 488 | 25.0 | 75.0 | ||
| 15 | | Cardinals | -22 | 12/23/2018 | vs | L 9-31 | 1 | 15 | 263 | 461 | 18.2 | 50.0 | ||
| 16 | | Cardinals | -21 | 10/29/2012 | vs | L 3-24 | 0 | 16 | 265 | 317 | 14.3 | 50.0 | ||
| 17 | | Cardinals | -21 | 11/29/2010 | vs | L 6-27 | 0 | 8 | 203 | 386 | 18.2 | 0.0 | ||
| 18 | | Cardinals | -21 | 9/27/2009 | vs | L 10-31 | 1 | 21 | 323 | 505 | 28.6 | 50.0 | ||
| 19 | | Cardinals | -21 | 12/14/2008 | vs | L 14-35 | 2 | 16 | 316 | 396 | 30.8 | 66.7 | ||
| 20 | | Cardinals | -21 | 11/24/2002 | vs | L 20-41 | 3 | 15 | 263 | 520 | 16.7 | 100.0 | ||
| 21 | | Cardinals | -21 | 11/10/2002 | vs | L 6-27 | 0 | 19 | 337 | 406 | 50.0 | |||
| 22 | | Cardinals | -21 | 9/23/2001 | vs | L 17-38 | 2 | 14 | 308 | 381 | 22.2 | 100.0 | ||
| 23 | | Cardinals | -20 | 9/30/2001 | vs | L 14-34 | 2 | 21 | 335 | 379 | 37.5 | 0.0 | ||
| 24 | | Cardinals | -19 | 11/16/2025 | vs | L 22-41 | 3 | 24 | 488 | 281 | 42.9 | |||
| 25 | | Cardinals | -19 | 10/15/2000 | vs | L 14-33 | 2 | 17 | 305 | 391 | 28.6 | 50.0 | ||
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More Cardinals Stats
Team Leaders 
PASS
3,366
Brissett
RUSH
333
Carter
REC
1,239
McBride
Team Rankings
PPG
20.9
23rd
OPP PPG
28.7
29th
RUSH YDS/G
93.1
31st
PASS YDS/G
256.1
5th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |