The Rock Island Independents have the highest point differential by a team in a Week-3 game, with a 60-point differential versus the Evansville Crimson Giants on October 15, 1922.
| TEAM | DIFF | DATE | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Independents | 60 | 10/15/1922 | vs | W 60-0 | ||||||||
| 2 | | Independents | 56 | 10/14/1923 | vs | W 56-0 | ||||||||
| 3 |  | Colts | 52 | 9/27/1964 | vs | W 52-0 | 7 | 20 | 456 | 241 | ||||
| 4 |  | Dolphins | 50 | 9/24/2023 | vs | W 70-20 | 10 | 30 | 726 | 363 | 55.6 | 33.3 | ||
| 5 |  | Packers | 49 | 9/30/1962 | vs | W 49-0 | 7 | 21 | 409 | 176 | ||||
| 6 |  | 49ers | 49 | 10/1/1961 | @ | W 49-0 | 7 | 23 | 317 | 291 | ||||
| 7 |  | Browns | 45 | 10/14/1951 | vs | W 45-0 | 6 | 21 | 376 | 255 | ||||
| 8 |  | Falcons | 42 | 9/18/2014 | vs | W 56-14 | 8 | 26 | 488 | 217 | 72.7 | |||
| 9 |  | Jets | 42 | 9/18/1988 | vs | W 45-3 | 6 | 28 | 395 | 237 | ||||
| 10 |  | Cardinals | 42 | 10/2/1950 | vs | W 55-13 | 8 | 27 | 553 | 186 | ||||
| 11 |  | Cardinals | 40 | 9/27/2015 | vs | W 47-7 | 6 | 28 | 446 | 156 | 46.2 | 100.0 | ||
| 12 | | Jets | 39 | 9/18/1966 | vs | W 52-13 | 7 | 23 | 466 | 207 | ||||
| 13 |  | Lions | 39 | 9/28/1936 | vs | W 39-0 | ||||||||
| 14 |  | Vikings | 38 | 9/21/2025 | vs | W 48-10 | 6 | 22 | 352 | 171 | 33.3 | 100.0 | ||
| 15 |  | Panthers | 38 | 9/22/2013 | vs | W 38-0 | 5 | 27 | 402 | 150 | 57.1 | 50.0 | ||
| 16 |  | Jets | 38 | 9/20/1998 | vs | W 44-6 | 6 | 28 | 505 | 310 | 63.6 | |||
| 17 |  | Bills | 38 | 9/20/1992 | vs | W 38-0 | 5 | 24 | 380 | 140 | 50.0 | |||
| 18 |  | All-Americans | 38 | 10/9/1921 | vs | W 38-0 | ||||||||
| 19 | | Bills | 37 | 9/23/2024 | vs | W 47-10 | 6 | 25 | 388 | 239 | 54.5 | 100.0 | ||
| 20 |  | Jaguars | 37 | 9/24/2017 | vs | W 44-7 | 5 | 24 | 410 | 186 | 25.0 | 100.0 | ||
| 21 | Pros | 37 | 10/10/1920 | vs | W 37-0 | |||||||||
| 22 |  | Steelers | 36 | 10/5/1975 | @ | W 42-6 | 6 | 23 | 501 | 221 | ||||
| 23 | | Packers | 36 | 10/7/1945 | vs | W 57-21 | 8 | 7 | ||||||
| 24 |  | Eagles | 35 | 9/23/2007 | vs | W 56-21 | 8 | 29 | 536 | 432 | 37.5 | |||
| 25 |  | Cowboys | 35 | 9/30/1973 | vs | W 45-10 | 6 | 31 | 578 | 290 | ||||
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| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
